Abstract: The present invention relates to methods for predicting prognosis and overall survival among tumour/cancer patients, and methods for classifying and stratifying these patients, particularly patients having pancreatic neuroendocrine tumors (PanNETs). The invention also relates to therapeutic methods for treating classified patients. Measuring gene expression levels of at least some of a selected group 198 genes is shown to be useful in the stratification of patients into groups with prognostic significance, and making a prediction of prognosis.

Abstract: The invention is generally applicable in the field of biomedical engineering, and specifically relates to a method for diagnosis and/or prognosis of neoplasias in animals. The invention further relates to a diagnostic/prognostic kit associated to such method, a reagent for the preparation of such kit and the use of particular biomarkers in such method and/or kit. The method comprises at leas the steps of: drawing at least one sample from the patient and determining the amount of a biomarker in said at least one sample drawn from the patient. The biomarker is a protein released by pancreatic cells.