Abstract: A computer system for matching clinic trials and patients includes a patient database to store at least one patient profile associated with a patient and a trials database to store at least one trial profile associated with a clinical trial. In response to receiving new information relating to a patient or a clinical trial a feature extraction module determines whether a patient profile or trial profile corresponding to the received information can be found in the database, identifies and extracts features, and activates an update flag. If a corresponding profile is found, the existing profile is updated based on the extracted features. If not found, a new profile is created and stored based on extracted features. An inference module generates a report linking at least one patient with at least one clinical trial based on comparison of extracted features associated with the stored patient profiles and the stored trial profiles.