Patents by Inventor Alec C. Kimmelman

Alec C. Kimmelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING SLC38A2 IN PANCREATIC CANCER
    Publication number: 20220275376
    Abstract: The present disclosure provides compositions and methods for interfering with uptake of neutral amino acids (e.g., alanine) in pancreatic cells. Alanine uptake can be inhibited by inhibiting the function and/or expression of SLC38A2 and/or SLC1A4.
    Type: Application
    Filed: August 20, 2020
    Publication date: September 1, 2022
    Inventors: Alec C. KIMMELMAN, Seth J. PARKER
  • Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
    Patent number: 10837015
    Abstract: Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: November 17, 2020
    Assignees: Dana-Farber Cancer Institute, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Alec C. Kimmelman, Jaekyoung Son, Lewis Cantley, Costas A. Lyssiotis
  • Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
    Patent number: 10350264
    Abstract: Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: July 16, 2019
    Assignees: Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College, Beth Israel Deaconess Medical Center, Inc., The Brigham & Women's Hospital, Inc.
    Inventors: Alec C. Kimmelman, Joseph D. Mancias, Jeffrey Wade Harper
  • TARGETING THE GLUTAMINE TO PYRUVATE PATHWAY FOR TREATMENT OF ONCOGENIC KRAS-ASSOCIATED CANCER
    Publication number: 20190136238
    Abstract: Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided.
    Type: Application
    Filed: October 12, 2018
    Publication date: May 9, 2019
    Inventors: Alec C. Kimmelman, Jaekyoung Son, Lewis Cantley, Costas A. Lyssiotis
  • Methods for diagnosing and treating oncogenic kras-associated cancer
    Patent number: 9745631
    Abstract: Methods for diagnosing and treating cancer associated with an oncogenic Kras mutation in a subject are provided.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: August 29, 2017
    Assignees: Dana-Farber Cancer Institute, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Ronald A. DePinho, Lewis Cantley, Alec C. Kimmelman, Haoqiang Ying, Costas A. Lyssiotis
  • Compositions And Methods For Modulating NCOA4-Mediated Autophagic Targeting Of Ferritin
    Publication number: 20170182119
    Abstract: Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.
    Type: Application
    Filed: March 27, 2015
    Publication date: June 29, 2017
    Inventors: Alec C. Kimmelman, Joseph D. Mancias, Jeffrey Wade Harper
  • METHODS FOR DIAGNOSING AND TREATING ONCOGENIC KRAS-ASSOCIATED CANCER
    Publication number: 20150126580
    Abstract: Methods for diagnosing and treating cancer associated with an oncogenic Kras mutation in a subject are provided.
    Type: Application
    Filed: December 19, 2012
    Publication date: May 7, 2015
    Inventors: Ronald A. DePinho, Lewis Cantley, Alec C. Kimmelman, Haoqiang Ying, Costas A. Lyssiotis
  • TARGETING THE GLUTAMINE TO PYRUVATE PATHWAY FOR TREATMENT OF ONCOGENIC KRAS-ASSOCIATED CANCER
    Publication number: 20150110773
    Abstract: Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided.
    Type: Application
    Filed: May 23, 2013
    Publication date: April 23, 2015
    Inventors: Alec C. Kimmelman, Jaekyoung Son, Lewis Cantley, Costas A. Lyssiotis