Patents by Inventor Alec Fettes

Alec Fettes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12084454
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: September 10, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Lukas Chytil, Serena Maria Fantasia, Alec Fettes, Ursula Hoffmann
  • Patent number: 11780834
    Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: October 10, 2023
    Assignees: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Cheol Keun Chung, Jie Xu, Hans Iding, Kyle Clagg, Michael Dalziel, Alec Fettes, Francis Gosselin, Ngiap-Kie Lim, Andrew McClory, Haiming Zhang, Paroma Chakravarty, Karthik Nagapudi, Sarah Robinson
  • Patent number: 11661424
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: May 30, 2023
    Assignee: Genentech, Inc.
    Inventors: Danial Beaudry, Theresa Cravillion, Francis Gosselin, Ngiap-Kie Lim, Sushant Malhotra, Qingping Tian, Haiming Zhang, Alexander Gmehling, Alec Fettes, Stephan Bachmann
  • Patent number: 10954234
    Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 23, 2021
    Assignees: Genentech, Inc., Hoffmann-La Roche, Inc.
    Inventors: Cheol Keun Chung, Jie Xu, Hans Iding, Kyle Clagg, Michael Dalziel, Alec Fettes, Francis Gosselin, Ngiap-Kie Lim, Andrew McClory, Haiming Zhang, Paroma Chakravarty, Karthik Nagapudi, Sarah Robinson
  • Patent number: 10882864
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: January 5, 2021
    Assignee: Genentech, Inc.
    Inventors: Danial Beaudry, Theresa Cravillion, Francis Gosselin, Ngiap-Kie Lim, Sushant Malhotra, Qingping Tian, Haiming Zhang, Alexander Gmehling, Alec Fettes, Stephan Bachmann
  • Patent number: 10385058
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: August 20, 2019
    Assignee: Genentech, Inc.
    Inventors: Danial Beaudry, Theresa Cravillion, Francis Gosselin, Ngiap-Kie Lim, Sushant Malhotra, Qingping Tian, Haiming Zhang, Alexander Gmehling, Alec Fettes, Stephan Bachmann
  • Publication number: 20160090360
    Abstract: The present invention provides a one step carbonylation of a compound of formula II in the presence of water to afford a compound of formula (I), useful in processes to manufacture BACE inhibitors.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 31, 2016
    Inventors: Alec Fettes, Hans-Peter Marty, Michelangelo Scalone
  • Publication number: 20150126743
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 7, 2015
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • Publication number: 20130338366
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: July 29, 2013
    Publication date: December 19, 2013
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • Patent number: 8420818
    Abstract: The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R2, R3 and R4 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower alkoxycarbonyl, aryl and heterocyclyl, and the pharmaceutically acceptable salts thereof. The pyrido[2,1-a]isoquinoline derivatives of the formula I are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: April 16, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes
  • Publication number: 20130018191
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 17, 2013
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • Publication number: 20120035368
    Abstract: The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R2, R3 and R4 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower alkoxycarbonyl, aryl and heterocyclyl, and the pharmaceutically acceptable salts thereof. The pyrido[2,1-a]isoquinoline derivatives of the formula I are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Application
    Filed: October 17, 2011
    Publication date: February 9, 2012
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes
  • Publication number: 20120022260
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: October 4, 2011
    Publication date: January 26, 2012
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • Publication number: 20110054174
    Abstract: The present invention relates to a process for the preparation of a compound of formula I, wherein R1 is C1-6-alkyl and R2 is hydrogen or halogen. (R)-2-phenyl propionic acid derivatives of formula I are key intermediates in the synthesis of 5-substituted-pyrazine or pyridine glucokinase activators of the formula Xa, which have the potential to be useful for the treatment and/or prophylaxis of type II diabetes.
    Type: Application
    Filed: August 20, 2010
    Publication date: March 3, 2011
    Inventors: Stephan Bachmann, Alec Fettes, Hans Iding, Beat Wirz, Ulrich Zutter
  • Publication number: 20110040091
    Abstract: The present invention relates to a process for the preparation of (R)-2-phenyl propionic acid derivatives of the formula wherein R1 is C1-6-alkyl and R2 is hydrogen or halogen, or of a salt thereof.
    Type: Application
    Filed: July 26, 2010
    Publication date: February 17, 2011
    Inventors: Stephan Bachmann, Alec Fettes, Michelangelo Scalone
  • Patent number: 7619101
    Abstract: This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: November 17, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Joseph Foricher, Bruno Lohri, Patrizio Mattei, Gerard Moine, Rudolf Schmid, Ulrich Zutter
  • Publication number: 20090163718
    Abstract: The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R2, R3 and R4 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower alkoxycarbonyl, aryl and heterocyclyl, and the pharmaceutically acceptable salts thereof. The pyrido[2,1-a]isoquinoline derivatives of the formula I are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Application
    Filed: December 3, 2008
    Publication date: June 25, 2009
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes
  • Publication number: 20080071087
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 20, 2008
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • Publication number: 20060270853
    Abstract: This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Application
    Filed: May 19, 2006
    Publication date: November 30, 2006
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Joseph Foricher, Bruno Lohri, Patrizio Mattei, Gerard Moine, Rudolf Schmid, Ulrich Zutter