Patents by Inventor Alec Fettes

Alec Fettes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF PYRIDO [2,1-a] ISOQUINOLINE DERIVATIVES COMPRISING OPTICAL RESOLUTION OF AN ENAMINE
    Publication number: 20120022260
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: October 4, 2011
    Publication date: January 26, 2012
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND
    Publication number: 20110054174
    Abstract: The present invention relates to a process for the preparation of a compound of formula I, wherein R1 is C1-6-alkyl and R2 is hydrogen or halogen. (R)-2-phenyl propionic acid derivatives of formula I are key intermediates in the synthesis of 5-substituted-pyrazine or pyridine glucokinase activators of the formula Xa, which have the potential to be useful for the treatment and/or prophylaxis of type II diabetes.
    Type: Application
    Filed: August 20, 2010
    Publication date: March 3, 2011
    Inventors: Stephan Bachmann, Alec Fettes, Hans Iding, Beat Wirz, Ulrich Zutter
  • PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES
    Publication number: 20110040091
    Abstract: The present invention relates to a process for the preparation of (R)-2-phenyl propionic acid derivatives of the formula wherein R1 is C1-6-alkyl and R2 is hydrogen or halogen, or of a salt thereof.
    Type: Application
    Filed: July 26, 2010
    Publication date: February 17, 2011
    Inventors: Stephan Bachmann, Alec Fettes, Michelangelo Scalone
  • Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2H-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
    Patent number: 7619101
    Abstract: This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: November 17, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Joseph Foricher, Bruno Lohri, Patrizio Mattei, Gerard Moine, Rudolf Schmid, Ulrich Zutter
  • PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES
    Publication number: 20090163718
    Abstract: The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R2, R3 and R4 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower alkoxycarbonyl, aryl and heterocyclyl, and the pharmaceutically acceptable salts thereof. The pyrido[2,1-a]isoquinoline derivatives of the formula I are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Application
    Filed: December 3, 2008
    Publication date: June 25, 2009
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes
  • PROCESS FOR THE PREPARATION OF PYRIDO [2,1-a] ISOQUINOLINE DERIVATIVES COMPRISING OPTICAL RESOLUTION OF AN ENAMINE
    Publication number: 20080071087
    Abstract: This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2? is the conjugate base of the resolving agent.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 20, 2008
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Stefan Hildbrand
  • Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
    Publication number: 20060270853
    Abstract: This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Application
    Filed: May 19, 2006
    Publication date: November 30, 2006
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Joseph Foricher, Bruno Lohri, Patrizio Mattei, Gerard Moine, Rudolf Schmid, Ulrich Zutter