Patents by Inventor Alec GROSS

Alec GROSS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-GD2 ANTIBODIES, IMMUNOCONJUGATES AND THERAPEUTIC USES THEREOF
    Publication number: 20250186603
    Abstract: The invention provides antibodies which bind human GD2 protein, as well as isolated nucleic acids and host cells comprising a sequence encoding said antibodies. The invention also provides immunoconjugates comprising said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions comprising antibodies or immunoconjugates of the invention. The invention also provides use of the antibodies, immunoconjugates and pharmaceutical compositions of the invention for the treatment of cancer or for diagnostic purposes.
    Type: Application
    Filed: March 8, 2023
    Publication date: June 12, 2025
    Inventors: Sean D. MCKENNA, Alec GROSS, Jianguo MA, Julia DOTTERWEICH, Nicolas RASCHE, Min SHAN, Christiane AMENDT, Jan ANDERL, Willem SLOOT
  • PROTEINS THAT BIND CD80 AND/OR CD86, AND OX40L
    Publication number: 20240262922
    Abstract: This disclosure relates generally to proteins that inhibit T cell costimulatory signaling comprising: a polypeptide or complex of two or more polypeptides that specifically binds CD80 and/or CD86, and a polypeptide or complex of two or more polypeptides that specifically binds OX40L. In some embodiments, the present application provides antibodies that specifically bind OX40L. In some embodiments the application also provides therapeutic methods for using such proteins in the treatment of autoimmune diseases.
    Type: Application
    Filed: December 6, 2023
    Publication date: August 8, 2024
    Inventors: Alec Gross, Chia Chi Sun, Gang Chen, Yves Fomekong Nanfack, Qi An, Bijan Zakeri, Qingyong Ji
  • Domain-exchanged antibody
    Patent number: 10982008
    Abstract: The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: April 20, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Gordana Wozniak-Knopp, Sylvia Dietrich, Florian Rüker, Alec Gross, Stefan Becker
  • DOMAIN-EXCHANGED ANTIBODY
    Publication number: 20180016354
    Abstract: The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.
    Type: Application
    Filed: December 4, 2015
    Publication date: January 18, 2018
    Inventors: Gordana WOZNIAK-KNOPP, Sylvia DIETRICH, Florian RÜKER, Alec GROSS, Stefan BECKER