Patents by Inventor Alec H. Christian

Alec H. Christian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC CYANOENONE DERIVATIVES AS MODULATORS OF KEAP1
    Publication number: 20230257371
    Abstract: The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.
    Type: Application
    Filed: July 15, 2021
    Publication date: August 17, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Michael D. Altman, David A. Canditio, Alec H. Christian, Ornella Di Pietro, Min Lu, Umar Faruk Mansoor, Katrina Marie Mennie, Andrew J. Musacchio, Anandan Palani, Michael H. Reutershan, David Matthew Shaw, Ping Lui, Stephen St-Gallay
  • Urea-oxaziridines
    Patent number: 11155530
    Abstract: Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: October 26, 2021
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, F. Dean Toste, Alec H. Christian, Patti Zhang
  • Urea-Oxaziridines
    Publication number: 20210155600
    Abstract: Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 27, 2021
    Applicant: The Regents of the University of California
    Inventors: Christopher J. Chang, F. Dean Toste, Alec H. Christian, Patti Zhang