Patents by Inventor Alec S.T. SMITH

Alec S.T. SMITH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ENHANCING MATURATION STATES OF HEALTHY AND DISEASED CARDIOMYOCYTES
    Publication number: 20200224168
    Abstract: The methods and compositions as disclosed herein describe the making of mature stem cell-derived cardiomyocytes for applications such as disease modeling, cardiotoxicity screening, drug screening and identification, among other uses. The methods involve physical and biochemical cues that promote a transition of stem cell-derived cardiomyocytes from a fetal phenotype to a more mature phenotype that more closely resembles that of adult cardiomyocytes.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 16, 2020
    Applicant: University of Washington
    Inventors: Deok-Ho KIM, Jesse MACADANGDANG, Alec S.T. SMITH, Hannele RUOHOLA-BAKER, Jason Wayne MIKLAS
  • DEVICE, SYSTEM AND METHODS FOR ELECTROPHYSIOLOGICAL INTERROGATION OF CELLS AND TISSUES
    Publication number: 20200055041
    Abstract: An apparatus for biological analysis includes a substrate, and an ion-permeable material with a textured surface on a first side of the ion-permeable material. The substrate is disposed proximate to a second side of the ion-permeable material, opposite the first side. A plurality of electrodes is disposed between the substrate and the ion-permeable material, where individual electrodes in the plurality of electrodes are positioned to measure an electrical signal that passes through the ion-permeable material.
    Type: Application
    Filed: April 6, 2018
    Publication date: February 20, 2020
    Inventors: Deok-Ho KIM, Alec S.T. SMITH, Eunpyo CHOI, Kevin GRAY