Abstract: The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Abstract: A utility is provided for generating applications for a variety of data conversion or handling application environments. A user can use a graphical user interface to purpose application adaptable modules to define a desired application. In one implementation, the user interface includes a node tree panel and a process assembly panel. The node tree panel lists tool sets including transformations, maps and input-output tools. These tools can then be assembled together with identified data sources and then elements using the assembly panel to define an application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application.

Abstract: A machine based tool and associated logic and methodology used in converting data from an input form to a target form using context dependent conversion rules. A frame-slot architecture is utilized where a frame represents an intersection between a contextual cue recognized by the machine tool, associated content and related constraint information to specific to that conversion environment. A slot represents an included chunk of information. An exemplary conversion system (400) includes a parser (402) for use in parsing and converting an input stream (403) to provide an output stream (411) in a form for use by a target system (412). The parser (402) uses information from a public schema (406), a private schema (408) and a grammar (410). The public schema (406), private schema (408) and grammar (410) may include conversion rules applicable to less than the whole of a subject matter area including the input stream (403).

Abstract: A utility is provided for generating applications for a variety of data conversion or handling application environments. A user can use a graphical user interface to purpose application adaptable modules to define a desired application. In one implementation, the user interface (1500) includes a node tree panel (1502) and a process assembly panel (1504). The node tree panel (1502) lists tool sets (1508) including transformations, maps and input-output tools. These tools can then be assembled together with identified data sources and then elements using the assembly panel (1504) to define an application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application.

Abstract: A utility is provided for generating applications for a variety of data conversion or handling application environments. A user can use a graphical user interface to purpose application adaptable modules to define a desired application. In one implementation, the user interface (1500) includes a node tree panel (1502) and a process assembly panel (1504). The node tree panel (1502) lists tool sets (1508) including transformations, maps and input-output tools. These tools can then be assembled together with identified data sources and then elements using the assembly panel (1504) to define an application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application.

Abstract: A machine based tool and associated logic and methodology arc used in converting data from an input form to a target form using context dependent conversion rules. A frame-slot architecture is utilized where a frame represents an intersection between a contextual cue recognized by the machine tool, associated content and related constraint information to specific to that conversion environment. A slot represents an included chunk of information. An exemplary conversion system (400) includes a parser (402) for use in parsing and converting an input stream (403) to provide an output stream (411) in a form for use by a target system (412). The parser (402) uses information from a public schema (406), a private schema (408) and a grammar (410). The public schema (406), private schema (408) and grammar (410) may include conversion rules applicable to less than the whole of a subject matter area including the input stream (403).

Abstract: A utility is provided for generating applications for a variety of data conversion or handling application environments. A user can use a graphical user interface to purpose application adaptable modules to define a desired application. In one implementation, the user interface (1500) includes a node tree panel (1502) and a process assembly panel (1504). The node tree panel (1502) lists tool sets (1508) including transformations, maps and input-output tools. These tools can then be assembled together with identified data sources and then elements using the assembly panel (1504) to define an application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application.

Abstract: A machine based tool and associated logic and methodology are used in converting data from an input form to a target form using context dependent conversion rules, and in efficiency generating an index that may be utilized to access the converted data in a database. Once the data has been converted, an index data structure for each data object may be automatically generated that encodes one or more characteristics or attributes of the converted data so that an entity may access the data using the index structure. As an example, the one or more characteristics may include categories, subcategories, or other attributes of the data.

Abstract: A utility is provided for generating applications for a variety of data conversion or handling application environments. A user can use a graphical user interface to purpose application adaptable modules to define a desired application. In one implementation, the user interface (1500) includes a node tree panel (1502) and a process assembly panel (1504). The node tree panel (1502) lists tool sets (1508) including transformations, maps and input-output tools. These tools can then be assembled together with identified data sources and then elements using the assembly panel (1504) to define an application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application.

Abstract: A machine based tool and associated logic and methodology are used in converting data from an input form to a target form using context dependent conversion rules. In particular, a frame-slot architecture is utilized where a frame represents an intersection between a contextual cue recognized by the machine tool, associated content and related constraint information to specific to that conversion environment, whereas a slot represents an included chunk of information. An exemplary conversion system (400) includes a parser (402) for use in parsing and converting an input stream (403) from a source (404) to provide an output stream (411) in a form for use by a target system (412). To accomplish the desired conversion, the parser (402) uses information from a public schema (406), a private schema (408) and a grammar (410). The public schema (406), private schema (408) and grammar (410) may include conversion rules applicable to less than the whole of a subject matter area including the input stream (403).

Abstract: A utility is provided for generating applications for a variety of data conversion or handling application environments. A user can use a graphical user interface to purpose application adaptable modules to define a desired application. In one implementation, the user interface (1500) includes a node tree panel (1502) and a process assembly panel (1504). The node tree panel (1502) lists tool sets (1508) including transformations, maps and input-output tools. These tools can then be assembled together with identified data sources and then elements using the assembly panel (1504) to define an application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application. In this manner, an application is generated from a number of generic modules simply by linking the modules to perform a purpose of the desired application.

Abstract: A method and apparatus are disclosed for transforming information from one semantic environment to another, for example, to facilitate electronic information searches. In one implementation, a SOLx system 1700 includes a Normalization/Translation NorTran Workbench 1702 and a SOLx server 1708. The NorTran Workbench 1702 is used to develop a knowledge base based on information from a source system 1712, to normalize legacy content 1710 according to various rules, and to develop a database 1706 of translated content. During run time, the SOLx server 1708 receives transmissions from the source system 1712, normalizes the transmitted content, accesses the database 1706 of translated content and otherwise translates the normalized content, and reconstructs the transmission to provide substantially real-time transformation of electronic messages. Additionally, content can be classified relative to a taxonomy defining relationships between terms or items so as to facilitate electronic searching or other processing.

Abstract: A machine based tool and associated logic and methodology are used in converting data from an input form to a target form using context dependent conversion rules. In particular, a frame-slot architecture is utilized where a frame represents an intersection between a contextual cue recognized by the machine tool, associated content and related constraint information to specific to that conversion environment, whereas a slot represents an included chunk of information. An exemplary conversion system (400) includes a parser (402) for use in parsing and converting an input stream (403) from a source (404) to provide an output stream (411) in a form for use by a target system (412). To accomplish the desired conversion, the parser (402) uses information from a public schema (406), a private schema (408) and a grammar (410). The public schema (406), private schema (408) and grammar (410) may include conversion rules applicable to less than the whole of a subject matter area including the input stream (403).