Abstract: Packaging with a safety opening, for containing products with restricted access. The packaging comprises an outer casing (4) with an outer body (5) equipped with a front portion with a front opening (6), a container (1) with a container body (3) with a front portion and which is intended to contain a product (2), the container (1) being slidable within the housing (4) through the opening (6) and at least one elongated protrusion (7) protruding from the container body (3) in the front portion of the container body (3). The casing (4) comprises, in correspondence with each protrusion (7), a recess (8) in the front portion of the outer body (5) in order to house the corresponding protrusion (7). In the closed position, each protrusion (7) does not protrude from the recess (8) thereof or from the outer body (5).