Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.

Abstract: In one embodiment, a method includes rendering a first sequence of image frames for displays of the extended reality (XR) display device in XR environment, wherein the first sequence of images portrays a virtual content organizer with multiple user-interactable elements corresponding to a first respective multiple operations, wherein the virtual content organizer is in a first pose, wherein a first subset of user-interactable elements of multiple user-interactable elements is selectable from the first pose, receiving one or more first gesture inputs associated with a first manipulation of the virtual content organizer along six degrees of freedom from the first pose to a second pose, rendering a second sequence of image frames, wherein the second sequence of images portrays the virtual content organizer in the second pose, receiving a selection of a particular user-interactable element from a second subset of user-interactable elements in a second pose, and executing the particular operation.

Abstract: In one embodiment, a method includes rendering a first sequence of image frames for displays of the extended reality (XR) display device in XR environment, wherein the first sequence of images portrays a virtual content organizer with multiple user-interactable elements corresponding to a first respective multiple operations, wherein the virtual content organizer is in a first pose, wherein a first subset of user-interactable elements of multiple user-interactable elements is selectable from the first pose, receiving one or more first gesture inputs associated with a first manipulation of the virtual content organizer along six degrees of freedom from the first pose to a second pose, rendering a second sequence of image frames, wherein the second sequence of images portrays the virtual content organizer in the second pose, receiving a selection of a particular user-interactable element from a second subset of user-interactable elements in a second pose, and executing the particular operation.

Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.

Abstract: The present invention provides a patch deployment device, the device comprising a pusher wire having a proximal end and a distal end; a plurality of deployment wires, wherein each deployment wire: has a first end and a second end, and the first end and the second end are connected to the distal end of the pusher wire; and is configured to be in an unexpanded state when positioned and constrained within a catheter, and configured to self-expand into an expanded state when positioned beyond a distal end of the catheter and not constrained, wherein in the expanded state at least a portion of the wire is positioned substantially within a plane that is substantially perpendicular to the longitudinal axis of the pusher wire and has an asymmetric form when viewed along a direction parallel to the longitudinal axis of the pusher wire.

Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.

Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.

Abstract: The present invention relates to polynucleotides and alphaviral vectors for the expression of genes of interest in mammalian cells. Additionally, the invention relates to cells which comprise said polynucleotides and alphaviral vectors and are capable of stably expressing one or more genes of interest. The invention also relates to methods for obtaining said cells, to methods for expressing a gene of interest in said cells, and to methods for replacing the gene of interest stably expressed by said cells with another gene of interest.

Abstract: The present invention relates to polynucleotides and alphaviral vectors for the expression of genes of interest in mammalian cells. Additionally, the invention relates to cells which comprise said polynucleotides and alphaviral vectors and are capable of stably expressing one or more genes of interest. The invention also relates to methods for obtaining said cells, to methods for expressing a gene of interest in said cells, and to methods for replacing the gene of interest stably expressed by said cells with another gene of interest.