Patents by Inventor Alejandro Benjamin Balazs

Alejandro Benjamin Balazs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reversible gene expression
    Patent number: 9943611
    Abstract: According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of interest and comprising a plurality of recombinase target sites are provided. In some embodiments, a source of recombinase is provided. In some embodiments, the gene product of interest is expressed, and the recombinase then induces recombination events between the recombinase target sites, thus reducing or eliminating expression of the gene product of interest.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: April 17, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Alejandro Benjamin Balazs, David Baltimore
  • Delivery of proteins using adeno-associated virus (AAV) vectors
    Patent number: 9527904
    Abstract: Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: December 27, 2016
    Assignee: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, David Baltimore
  • DELIVERY OF PROTEINS USING ADENO-ASSOCIATED VIRUS (AAV) VECTORS
    Publication number: 20150010578
    Abstract: Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 8, 2015
    Inventors: Alejandro Benjamin Balazs, David Baltimore
  • Delivery of proteins using adeno-associated virus (AAV) vectors
    Patent number: 8865881
    Abstract: Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: October 21, 2014
    Assignee: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, David Baltimore
  • REVERSIBLE GENE EXPRESSION
    Publication number: 20140127162
    Abstract: According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of interest and comprising a plurality of recombinase target sites are provided. In some embodiments, a source of recombinase is provided. In some embodiments, the gene product of interest is expressed, and the recombinase then induces recombination events between the recombinase target sites, thus reducing or eliminating expression of the gene product of interest.
    Type: Application
    Filed: October 30, 2013
    Publication date: May 8, 2014
    Applicant: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, David Baltimore
  • Isolation of unknown rearranged T-cell receptors from single cells
    Patent number: 8497071
    Abstract: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: July 30, 2013
    Assignee: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, Jonathan Michael Tsai, David Baltimore
  • DELIVERY OF PROTEINS USING ADENO-ASSOCIATED VIRUS (AAV) VECTORS
    Publication number: 20120232133
    Abstract: Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
    Type: Application
    Filed: February 21, 2012
    Publication date: September 13, 2012
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Alejandro Benjamin Balazs, David Baltimore
  • ISOLATION OF UNKNOWN REARRANGED T-CELL RECEPTORS FROM SINGLE CELLS
    Publication number: 20110014659
    Abstract: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.
    Type: Application
    Filed: June 28, 2010
    Publication date: January 20, 2011
    Applicant: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, Jonathan Michael Tsai, David Baltimore