Patents by Inventor Alejandro Bertorello

Alejandro Bertorello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identification of compounds that bind to &bgr;-tubulin and stimulate insulin secretion
    Patent number: 6586188
    Abstract: According to the invention &bgr;-tubulin, as well as a 65 kDa polypeptide present in pancreatic &bgr;-cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, thereby stimulating insulin secretion.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: July 1, 2003
    Assignee: Biovitrum AB
    Inventors: Per-Olof Berggren, Thomas Lundbäck, Alejandro Bertorello