Patents by Inventor Alejandro CASTREJON AGUILERA

Alejandro CASTREJON AGUILERA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of generating a synthetic embryo
    Patent number: 11959097
    Abstract: Methods of generating a synthetic embryo are provided. Accordingly, there is provided a method of generating a synthetic embryo comprising inducing expression of a factor that induces differentiation to trophectoderm cells in a subpopulation of naïve pluripotent stem cells (PSCs) to obtain a trophectoderm primed cells; inducing expression of a factor that induces differentiation to extra embryonic primitive endodermal cells in a second subpopulation of naïve PSCs to obtain extra embryonic primitive endodermal primed cells; and mixing said trophectoderm primed cells and said extra embryonic primitive endodermal primed cells with naïve PSCs under conditions that allow formation of aggregated cells. Also provided are articles of manufactures, mixtures and aggregates of cells and methods of using same.
    Type: Grant
    Filed: July 27, 2023
    Date of Patent: April 16, 2024
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yaqub Hanna, Sergey Viukov, Emilie Wildschutz, Noa Novershtern, Carine Joubran, Segev Naveh Tassa, Alejandro Castrejon Aguilera, Bernardo Oldak, Shadi Tarazi, Francesco Roncato
  • METHODS OF GENERATING A SYNTHETIC EMBRYO
    Publication number: 20240010973
    Abstract: Methods of generating a synthetic embryo are provided. Accordingly, there is provided a method of generating a synthetic embryo comprising inducing expression of a factor that induces differentiation to trophectoderm cells in a subpopulation of naïve pluripotent stem cells (PSCs) to obtain a trophectoderm primed cells; inducing expression of a factor that induces differentiation to extra embryonic primitive endodermal cells in a second subpopulation of naïve PSCs to obtain extra embryonic primitive endodermal primed cells; and mixing said trophectoderm primed cells and said extra embryonic primitive endodermal primed cells with naïve PSCs under conditions that allow formation of aggregated cells. Also provided are articles of manufactures, mixtures and aggregates of cells and methods of using same.
    Type: Application
    Filed: July 27, 2023
    Publication date: January 11, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yaqub HANNA, Sergey VIUKOV, Emilie WILDSCHUTZ, Noa NOVERSHTERN, Carine JOUBRAN, Segev NAVEH TASSA, Alejandro CASTREJON AGUILERA, Bernardo OLDAK, Shadi TARAZI, Francesco RONCATO