Patents by Inventor Alejandro Covalin

Alejandro Covalin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11351370
    Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: June 7, 2022
    Assignee: Spark Biomedical, Inc.
    Inventors: Alejandro Covalin, Navid Khodaparast, Daniel Powell
  • Publication number: 20210213286
    Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 15, 2021
    Inventors: Alejandro Covalin, Navid Khodaparast, Daniel Powell
  • Patent number: 10967182
    Abstract: Systems and methods for reducing pulmonary inflammation and/or increasing bronchial compliance in a patient utilize transcutaneous stimulation of neural structures in a region of an ear of a patient delivered by an auricular stimulation device having an in-ear component with a first electrode disposed in a patient's ear and an earpiece component with a second electrode placed around the auricle. A pulse generator may control delivery of therapy by delivering both a first series of stimulation pulses to the first electrode for stimulating a first neural structure(s) and a second series of stimulation pulses to the second electrode for stimulating second neural structure(s). The first and second electrodes are in non-piercing contact with tissue on and/or surrounding the ear. The systems and methods may be used to treat viral or bacteria infections, such as SARS, MERS, or COVID-19.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: April 6, 2021
    Assignee: Spark Biomedical, Inc.
    Inventors: Navid Khodaparast, Alejandro Covalin
  • Publication number: 20200238085
    Abstract: Systems and methods for reducing pulmonary inflammation and/or increasing bronchial compliance in a patient utilize transcutaneous stimulation of neural structures in a region of an ear of a patient delivered by an auricular stimulation device having an in-ear component with a first electrode disposed in a patient's ear and an earpiece component with a second electrode placed around the auricle. A pulse generator may control delivery of therapy by delivering both a first series of stimulation pulses to the first electrode for stimulating a first neural structure(s) and a second series of stimulation pulses to the second electrode for stimulating second neural structure(s). The first and second electrodes are in non-piercing contact with tissue on and/or surrounding the ear. The systems and methods may be used to treat viral or bacteria infections, such as SARS, MERS, or COVID-19.
    Type: Application
    Filed: April 10, 2020
    Publication date: July 30, 2020
    Inventors: Navid Khodaparast, Alejandro Covalin
  • Patent number: 10695568
    Abstract: A treatment system and method for inducing endogenous release of peptides is provided including a concha apparatus including a first electrode in contact with vagal related neural structures; an earpiece connected to the concha apparatus by a first connector, the earpiece including a PCB layer including a second electrode configured to be in contact with a neural structure related to the auriculotemporal nerve, and at least another electrode configured to be in contact with or in proximity to neural structures related to the great auricular nerve and/or its branches and/or the lesser occipital nerve and/or its branches, and an adhesive configured to secure the electrodes on the earpiece to the skin; and a pulse generator connected to the earpiece by a second connector, the pulse generator including circuitry in communication with the first electrode of the concha apparatus, the second electrode and the at least another electrode of the earpiece.
    Type: Grant
    Filed: July 14, 2019
    Date of Patent: June 30, 2020
    Assignee: Spark Biomedical, Inc.
    Inventor: Alejandro Covalin
  • Publication number: 20200197707
    Abstract: A treatment system and method for inducing endogenous release of peptides is provided including a concha apparatus including a first electrode in contact with vagal related neural structures; an earpiece connected to the concha apparatus by a first connector, the earpiece including a PCB layer including a second electrode configured to be in contact with a neural structure related to the auriculotemporal nerve, and at least another electrode configured to be in contact with or in proximity to neural structures related to the great auricular nerve and/or its branches and/or the lesser occipital nerve and/or its branches, and an adhesive configured to secure the electrodes on the earpiece to the skin; and a pulse generator connected to the earpiece by a second connector, the pulse generator including circuitry in communication with the first electrode of the concha apparatus, the second electrode and the at least another electrode of the earpiece.
    Type: Application
    Filed: July 14, 2019
    Publication date: June 25, 2020
    Applicant: Spark Biomedical, Inc
    Inventor: Alejandro Covalin
  • Patent number: 10322283
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 18, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Publication number: 20170259063
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 14, 2017
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Patent number: 9682236
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: June 20, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Patent number: 9597007
    Abstract: Disclosed herein are methods for identifying and targeting brain regions and brain structures. In one embodiment, a method of identifying a brain structure in a patient comprises imaging a brain region using Diffusion Tensor Imaging MRI to identify a nerve tract, following the nerve tract to a first brain structure, and identifying the first brain structure based on the location and orientation of the nerve tract.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: March 21, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, U.S. DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Antonio Alfonso Ferreira DeSalles, Alejandro Covalin
  • Publication number: 20160354139
    Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure sensing elements which may allow for control of the pressure within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled or room temperature fluid such as water may then be used to rapidly terminate the treatment session.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Daniel R. BURNETT, Alejandro COVALIN
  • Publication number: 20160129254
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Application
    Filed: January 19, 2016
    Publication date: May 12, 2016
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Patent number: 9238139
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: January 19, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Patent number: 9204828
    Abstract: A device may be implanted subcutaneously with an attached catheter inserted within, e.g., the peritoneal cavity of a subject. The catheter and/or device may also be inserted into another space, e.g., subcutaneous, vascular, peritoneal, cerebrospinal, pleural spaces, etc. The peritoneal fluid which normally collects and/or flows through the peritoneal cavity may be detected by the catheter and analyzed via the device to detect the concentration of glucose within the fluid.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 8, 2015
    Assignee: TheraNova, LLC
    Inventors: Daniel Rogers Burnett, Alejandro Covalin
  • Publication number: 20140236052
    Abstract: A battery-operated transcutaneous electrical nerve stimulator (TENS) to treat headache pain in an abortive and/or preventive manner. The TENS unit and its electrodes are built into a unitary device which facilitates a self-administered treatment. In some embodiments, the pulses are monophasic. In other embodiments, pairs of biphasic pulses are provided, wherein each pair of biphasic pulses includes a first pulse having a first polarity separated by a gap in time from a second pulsed having an opposite polarity. In some embodiments, each pulse in each biphasic pair is of a duration equal to that of the other pulse of the pair. In some embodiments, the duration of each pulse is between about 50 microseconds and about 400 microseconds, and the gap in time between pulses of a pair is between about 50 and 100 microseconds.
    Type: Application
    Filed: October 15, 2013
    Publication date: August 21, 2014
    Inventor: Alejandro Covalin
  • Publication number: 20140228906
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 14, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
  • Publication number: 20140188200
    Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.
    Type: Application
    Filed: March 4, 2014
    Publication date: July 3, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher M. DeGiorgio, Ian A. Cook, Alejandro Covalin
  • Publication number: 20140135886
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Application
    Filed: December 14, 2011
    Publication date: May 15, 2014
    Applicant: UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Ian A. Cook, Christopher M. Degiorgio, Leon Ekchian, Patrick Miller, Antonio Desalles, Alejandro Covalin
  • Publication number: 20140108025
    Abstract: The present invention extends to methods, systems, and computer program products for collecting and transferring physiological data. Different physiological monitoring appliances can be attached to a portable physiological data collection device. Each physiological monitoring appliance can collect a different physiological data (blood glucose data, heart rate data, etc.) from an individual. Different physiological data can be collected and stored at the portable physiological data collection device. In response to a triggering event, a connection can be established to an external computer system. The stored physiological data can be transferred over the established connection to the external computer system. In some embodiments, the external computer system is a healthcare server that shares collected physiological data as well as other healthcare information with designated entities (e.g., family, doctors, etc.).
    Type: Application
    Filed: March 13, 2013
    Publication date: April 17, 2014
    Inventors: Ruben Gerardo Echeverria Cabrera, Hugo Luis Villalobos Canto, Luis Alberto Munoz Ubando, Jose Ramon Atoche Ensenat, Freddy Antonio Ix Andrade, Alejandro Covalin Shaftman
  • Patent number: 8700164
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: April 15, 2014
    Assignee: The Regents of the University of California
    Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader