Patents by Inventor Alejandro Covalin
Alejandro Covalin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11351370Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.Type: GrantFiled: March 31, 2021Date of Patent: June 7, 2022Assignee: Spark Biomedical, Inc.Inventors: Alejandro Covalin, Navid Khodaparast, Daniel Powell
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Publication number: 20210213286Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.Type: ApplicationFiled: March 31, 2021Publication date: July 15, 2021Inventors: Alejandro Covalin, Navid Khodaparast, Daniel Powell
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Patent number: 10967182Abstract: Systems and methods for reducing pulmonary inflammation and/or increasing bronchial compliance in a patient utilize transcutaneous stimulation of neural structures in a region of an ear of a patient delivered by an auricular stimulation device having an in-ear component with a first electrode disposed in a patient's ear and an earpiece component with a second electrode placed around the auricle. A pulse generator may control delivery of therapy by delivering both a first series of stimulation pulses to the first electrode for stimulating a first neural structure(s) and a second series of stimulation pulses to the second electrode for stimulating second neural structure(s). The first and second electrodes are in non-piercing contact with tissue on and/or surrounding the ear. The systems and methods may be used to treat viral or bacteria infections, such as SARS, MERS, or COVID-19.Type: GrantFiled: April 10, 2020Date of Patent: April 6, 2021Assignee: Spark Biomedical, Inc.Inventors: Navid Khodaparast, Alejandro Covalin
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Publication number: 20200238085Abstract: Systems and methods for reducing pulmonary inflammation and/or increasing bronchial compliance in a patient utilize transcutaneous stimulation of neural structures in a region of an ear of a patient delivered by an auricular stimulation device having an in-ear component with a first electrode disposed in a patient's ear and an earpiece component with a second electrode placed around the auricle. A pulse generator may control delivery of therapy by delivering both a first series of stimulation pulses to the first electrode for stimulating a first neural structure(s) and a second series of stimulation pulses to the second electrode for stimulating second neural structure(s). The first and second electrodes are in non-piercing contact with tissue on and/or surrounding the ear. The systems and methods may be used to treat viral or bacteria infections, such as SARS, MERS, or COVID-19.Type: ApplicationFiled: April 10, 2020Publication date: July 30, 2020Inventors: Navid Khodaparast, Alejandro Covalin
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Patent number: 10695568Abstract: A treatment system and method for inducing endogenous release of peptides is provided including a concha apparatus including a first electrode in contact with vagal related neural structures; an earpiece connected to the concha apparatus by a first connector, the earpiece including a PCB layer including a second electrode configured to be in contact with a neural structure related to the auriculotemporal nerve, and at least another electrode configured to be in contact with or in proximity to neural structures related to the great auricular nerve and/or its branches and/or the lesser occipital nerve and/or its branches, and an adhesive configured to secure the electrodes on the earpiece to the skin; and a pulse generator connected to the earpiece by a second connector, the pulse generator including circuitry in communication with the first electrode of the concha apparatus, the second electrode and the at least another electrode of the earpiece.Type: GrantFiled: July 14, 2019Date of Patent: June 30, 2020Assignee: Spark Biomedical, Inc.Inventor: Alejandro Covalin
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Publication number: 20200197707Abstract: A treatment system and method for inducing endogenous release of peptides is provided including a concha apparatus including a first electrode in contact with vagal related neural structures; an earpiece connected to the concha apparatus by a first connector, the earpiece including a PCB layer including a second electrode configured to be in contact with a neural structure related to the auriculotemporal nerve, and at least another electrode configured to be in contact with or in proximity to neural structures related to the great auricular nerve and/or its branches and/or the lesser occipital nerve and/or its branches, and an adhesive configured to secure the electrodes on the earpiece to the skin; and a pulse generator connected to the earpiece by a second connector, the pulse generator including circuitry in communication with the first electrode of the concha apparatus, the second electrode and the at least another electrode of the earpiece.Type: ApplicationFiled: July 14, 2019Publication date: June 25, 2020Applicant: Spark Biomedical, IncInventor: Alejandro Covalin
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Patent number: 10322283Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: May 25, 2017Date of Patent: June 18, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Publication number: 20170259063Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: May 25, 2017Publication date: September 14, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Patent number: 9682236Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: January 19, 2016Date of Patent: June 20, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Patent number: 9597007Abstract: Disclosed herein are methods for identifying and targeting brain regions and brain structures. In one embodiment, a method of identifying a brain structure in a patient comprises imaging a brain region using Diffusion Tensor Imaging MRI to identify a nerve tract, following the nerve tract to a first brain structure, and identifying the first brain structure based on the location and orientation of the nerve tract.Type: GrantFiled: July 21, 2010Date of Patent: March 21, 2017Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, U.S. DEPARTMENT OF VETERANS AFFAIRSInventors: Antonio Alfonso Ferreira DeSalles, Alejandro Covalin
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Publication number: 20160354139Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure sensing elements which may allow for control of the pressure within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled or room temperature fluid such as water may then be used to rapidly terminate the treatment session.Type: ApplicationFiled: August 19, 2016Publication date: December 8, 2016Inventors: Daniel R. BURNETT, Alejandro COVALIN
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Publication number: 20160129254Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: January 19, 2016Publication date: May 12, 2016Inventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Patent number: 9238139Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: April 14, 2014Date of Patent: January 19, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Patent number: 9204828Abstract: A device may be implanted subcutaneously with an attached catheter inserted within, e.g., the peritoneal cavity of a subject. The catheter and/or device may also be inserted into another space, e.g., subcutaneous, vascular, peritoneal, cerebrospinal, pleural spaces, etc. The peritoneal fluid which normally collects and/or flows through the peritoneal cavity may be detected by the catheter and analyzed via the device to detect the concentration of glucose within the fluid.Type: GrantFiled: November 29, 2011Date of Patent: December 8, 2015Assignee: TheraNova, LLCInventors: Daniel Rogers Burnett, Alejandro Covalin
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Publication number: 20140236052Abstract: A battery-operated transcutaneous electrical nerve stimulator (TENS) to treat headache pain in an abortive and/or preventive manner. The TENS unit and its electrodes are built into a unitary device which facilitates a self-administered treatment. In some embodiments, the pulses are monophasic. In other embodiments, pairs of biphasic pulses are provided, wherein each pair of biphasic pulses includes a first pulse having a first polarity separated by a gap in time from a second pulsed having an opposite polarity. In some embodiments, each pulse in each biphasic pair is of a duration equal to that of the other pulse of the pair. In some embodiments, the duration of each pulse is between about 50 microseconds and about 400 microseconds, and the gap in time between pulses of a pair is between about 50 and 100 microseconds.Type: ApplicationFiled: October 15, 2013Publication date: August 21, 2014Inventor: Alejandro Covalin
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Publication number: 20140228906Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: April 14, 2014Publication date: August 14, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Publication number: 20140188200Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.Type: ApplicationFiled: March 4, 2014Publication date: July 3, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher M. DeGiorgio, Ian A. Cook, Alejandro Covalin
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Publication number: 20140135886Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: December 14, 2011Publication date: May 15, 2014Applicant: UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRSInventors: Ian A. Cook, Christopher M. Degiorgio, Leon Ekchian, Patrick Miller, Antonio Desalles, Alejandro Covalin
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Publication number: 20140108025Abstract: The present invention extends to methods, systems, and computer program products for collecting and transferring physiological data. Different physiological monitoring appliances can be attached to a portable physiological data collection device. Each physiological monitoring appliance can collect a different physiological data (blood glucose data, heart rate data, etc.) from an individual. Different physiological data can be collected and stored at the portable physiological data collection device. In response to a triggering event, a connection can be established to an external computer system. The stored physiological data can be transferred over the established connection to the external computer system. In some embodiments, the external computer system is a healthcare server that shares collected physiological data as well as other healthcare information with designated entities (e.g., family, doctors, etc.).Type: ApplicationFiled: March 13, 2013Publication date: April 17, 2014Inventors: Ruben Gerardo Echeverria Cabrera, Hugo Luis Villalobos Canto, Luis Alberto Munoz Ubando, Jose Ramon Atoche Ensenat, Freddy Antonio Ix Andrade, Alejandro Covalin Shaftman
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Patent number: 8700164Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: February 15, 2013Date of Patent: April 15, 2014Assignee: The Regents of the University of CaliforniaInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader