Patents by Inventor Alejandro Markovits Rojas
Alejandro Markovits Rojas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10836701Abstract: The present disclosure describes that high purity cholesterol is obtained by the processes of the invention without any further purification step, such as a crystallizing step from a solvent, but rather by distilling steps alone. The disclosures provides a process that includes the production of compositions having a cholesterol content over 75% in weight, from fish oil processing waste residues.Type: GrantFiled: March 26, 2020Date of Patent: November 17, 2020Inventors: Alejandro Markovits Rojas, Steven Lee Härting Eckman, Thomas Francis Härting Glade
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Publication number: 20200317597Abstract: The present disclosure describes that high purity cholesterol is obtained by the processes of the invention without any further purification step, such as a crystallizing step from a solvent, but rather by distilling steps alone. The disclosures provides a process that includes the production of compositions having a cholesterol content over 75% in weight, from fish oil processing waste residues.Type: ApplicationFiled: March 26, 2020Publication date: October 8, 2020Inventors: Alejandro MARKOVITS Rojas, Steven Lee HÄRTING Eckman, Thomas Francis HÄRTING Glade
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Patent number: 10196583Abstract: Disclosed is a process for producing cholesterol from fish oil, including the following steps: (a) distilling fish oil in a vacuum distillation column to obtain a first residue and a first distillate, (b) distilling the first distillate in a vacuum distillation column to obtain a second distillate and a second residue, (c) contacting the second residue with an alkali to produce a saponified mixture, (d) contacting the saponified mixture with a non-polar organic solvent or a mixture of non-polar organic solvents to produce an organic phase and an aqueous phase, (e) separating the organic phase from the aqueous phase, (f) cooling the organic phase to form a solid phase and a liquid phase, and (g) separating the solid phase from the organic phase, wherein the separated solid phase includes cholesterol.Type: GrantFiled: February 14, 2018Date of Patent: February 5, 2019Inventors: Alejandro Markovits Rojas, Thomas Francis Härting Glade, Steven Lee Härting Eckman
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Patent number: 10196586Abstract: Disclosed is a process for producing a composition involving: (a) distilling fish oil in a vacuum distillation column to obtain a first residue and first distillate, and (b) distilling the first distillate in a vacuum distillation column to obtain a second distillate and a second residue that includes a composition containing cholesterol, eicosapentaenoic acid, and docosahexaenoic acid. Also disclosed is a process for producing a composition involving: (a) distilling fish oil in a vacuum distillation column to obtain a first residue and first distillate, (b) distilling the first distillate in a vacuum distillation column to obtain a second distillate and second residue containing cholesterol, (c) esterifying the second residue to obtain a mixture containing cholesterol esters, and (d) distilling the mixture in a vacuum distillation column to obtain a third distillate and a third residue that includes a composition containing cholesterol esters of eicosapentaenoic acid and docosahexaenoic acid.Type: GrantFiled: February 14, 2018Date of Patent: February 5, 2019Assignee: GOLDEN OMEGA S.A.Inventors: Julio César Meza Almendra, José Luis Lopez Castillo, Pablo Napolitano Feito, Gustavo Adolfo Dorlhiac Silva, Luis Tomás Pincheira Varas, Alejandro Markovits Rojas
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Patent number: 10190074Abstract: Disclosed is a process for producing a cholesterol concentrate including the steps of (a) distilling a fish oil having no more than 2% free fatty acids in an admixture with an auxiliary fluid in a vacuum distillation column to obtain a first distillate and a first residue; and (b) distilling the first distillate in a vacuum distillation column to obtain a second distillate and a second residue, wherein the second residue includes the cholesterol concentrate.Type: GrantFiled: February 14, 2018Date of Patent: January 29, 2019Assignee: GOLDEN OMEGA S.A.Inventors: Julio César Meza Almendra, José Luis Lopez Castillo, Pablo Napolitano Feito, Gustavo Adolfo Dorlhiac Silva, Luis Tomás Pincheira Varas, Alejandro Markovits Rojas
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Patent number: 9629378Abstract: The invention relates to a method for the production of highly stable aqueous dispersions of phytosterols, phytostanols and derivatives thereof, which allows the use of a wide range of emulsifiers in relatively small concentrations in relation to the phytosterols and which allows the preparation of dispersions with high concentrations of phytosterols. Said dispersions are obtained using a method in which one or more phytosterols, an aqueous medium and one or more emulsifiers are dispersed in a disperser at a temperature of at least 140° C. in order to obtain an emulsion and the resulting emulsion is subsequently cooled in order to obtain a dispersion of sterols in an aqueous medium.Type: GrantFiled: January 29, 2010Date of Patent: April 25, 2017Inventors: Thomas Francis Harting Glade, Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas
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Patent number: 8981137Abstract: The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).Type: GrantFiled: September 3, 2013Date of Patent: March 17, 2015Assignee: Golden Omega S.A.Inventors: Tomas Francis Harting Glade, Miguel Angel Diaz Fuenzalida, Alejandro Markovits Rojas
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Patent number: 8957231Abstract: An efficient and simple process to obtain a concentrate that includes over 80% in weight of ethyl esters of ?-3 fatty acids based on a composition of matter that contains esters of ?-3 fatty acids or free ?-3 fatty acids that comprises the stages of: a) contacting the composition of matter with ethanol of at least 96% in weight and a hydroxide of an alkali metal at a temperature between 60 and 200° C. to form a liquid mixture that includes alkaline salts of fatty acids; b) cool the liquid mixture to a temperature between 50 and ?20° C. to form a solid phase and a liquid phase and separate the liquid phase from the solid phase; c) contact the separated liquid phase of stage b) with an acid to form an acidified mixture with a water content under 10%, where the mixture consists of a solid phase that includes the alkali metal salt of the acid and a liquid phase that comprises ?-3 fatty acids; d) heat the mixture of stage c) between 50 to 150° C.Type: GrantFiled: December 25, 2011Date of Patent: February 17, 2015Assignee: Golden Omega S.A.Inventors: Juvenal Antonio Sepulveda Reyes, Miriam Rosa Berrios Cornejo, Miguel Angel Fuenzalida Dias, Alejandro Markovits Rojas, Thomas Francis Harting Glade
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Patent number: 8916031Abstract: Described is a process to obtain tetracosanol from a complex mixture derived from tall oil pitch that comprises terpenoids, rosin alcohols, rosin aldehydes, aliphatic alcohols, hydrocarbons and stilbene derivatives. The process comprises a mixture crystallization step from hexane and a fractional distillation of the crystallized solids, which yields tetracosanol with more than 90% purity.Type: GrantFiled: May 10, 2010Date of Patent: December 23, 2014Assignees: Pontificia Universidad Catolica de Valparaiso, Harting S.A.Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Miriam Berrios Cornejo, Mabel Keller Mena, Jose Rodrigo Vergara Salinas, Glenda Cea Barcia, Andres Illanes Frontaura, Rolando Arturo Chamy Maggi, Andres Markovits Schersl, Araceli Olivares Miralles
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Patent number: 8791281Abstract: The invention is related to a process for production of lignoceric acid from mixtures of long-chain aliphatic alcohols that contain lignoceric alcohol, wherein the process consists in oxidizing the mixture in a biphasic catalytic system using quaternary ammonium peroxotungstophosphate as a catalyst and hydrogen peroxide as an oxidant, followed by several physical or chemical unitary steps to separate and purify the lignoceric acid.Type: GrantFiled: May 10, 2010Date of Patent: July 29, 2014Assignee: Pontificia Universidad Catolica de ValparaisoInventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Miriam Berrios Cornejo, Mabel Keller Mena, Jose Rodrigo Vergara Salinas, Glenda Cea Barcia, Andres Illanes Frontaura, Rolando Arturo Chamy Maggi, Andres Markovits Schersl, Araceli Olivares Miralles, Nadia Veronica Guajardo Ramirez
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Publication number: 20140005425Abstract: The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicant: Golden Omega S.A.Inventors: Tomas Francis Harting Glade, Miguel Angel Diaz Fuenzalida, Alejandro Markovits Rojas
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Patent number: 8586772Abstract: The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).Type: GrantFiled: June 1, 2010Date of Patent: November 19, 2013Assignee: Golden Omega S.A.Inventors: Tomas Francis Harting Glade, Miguel Angel Diaz Fuenzalida, Alejandro Markovits Rojas
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Publication number: 20130267600Abstract: An efficient and simple process to obtain a concentrate that includes over 80% in weight of ethyl esters of ?-3 fatty acids based on a composition of matter that contains esters of ?-3 fatty acids or free ?-3 fatty acids that comprises the stages of: a) contacting the composition of matter with ethanol of at least 96% in weight and a hydroxide of an alkali metal at a temperature between 60 and 200° C. to form a liquid mixture that includes alkaline salts of fatty acids; b) cool the liquid mixture to a temperature between 50 and ?20° C. to form a solid phase and a liquid phase and separate the liquid phase from the solid phase; c) contact the separated liquid phase of stage b) with an acid to form an acidified mixture with a water content under 10%, where the mixture consists of a solid phase that includes the alkali metal salt of the acid and a liquid phase that comprises ?-3 fatty acids; d) heat the mixture of stage c) between 50 to 150° C.Type: ApplicationFiled: December 25, 2011Publication date: October 10, 2013Applicant: Golden Omega S.A.Inventors: Juvenal Antonio Sepulveda Reyes, Miriam Rosa Berrios Cornejo, Miguel Angel Fuenzalida Dias, Alejandro Markovits Rojas, Thomas Francis Harting Glade
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Patent number: 8258330Abstract: Carrier fluid compositions and their use in processes for reducing the concentration of persistent organic pollutants, such as polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzo-p-furans (PCDDF), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and pesticides, such as chlorinated hydrocarbons, chlorinated toxaphenes and camphenes, in fish oil are disclosed. The process includes vacuum distillation of the fish oil in the presence of the carrier fluid compositions to provide a fish oil residue having a reduced concentration of persistent organic pollutants.Type: GrantFiled: January 4, 2012Date of Patent: September 4, 2012Assignee: Naturalis, S.A.Inventors: Thomas Francis Harting Glade, Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas
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Publication number: 20120083616Abstract: The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).Type: ApplicationFiled: June 1, 2010Publication date: April 5, 2012Applicant: GOLDEN OMEGA S.A.Inventors: Tomas Francis Harting Glade, Miguel Angel Diaz Fuenzalida, Alejandro Markovits Rojas
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Publication number: 20120046254Abstract: The invention relates to a method for the production of highly stable aqueous dispersions of phytosterols, phytostanols and derivatives thereof, which allows the use of a wide range of emulsifiers in relatively small concentrations in relation to the phytosterols and which allows the preparation of dispersions with high concentrations of phytosterols. Said dispersions are obtained using a method in which one or more phytosterols, an aqueous medium and one or more emulsifiers are dispersed in a disperser at a temperature of at least 140° C. in order to obtain an emulsion and the resulting emulsion is subsequently cooled in order to obtain a dispersion of sterols in an aqueous medium.Type: ApplicationFiled: January 29, 2010Publication date: February 23, 2012Inventors: Thomas Francis Harting Glade, Miguel Fuenzalida Diaz, Alejandro Markovits Rojas
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Patent number: 7087402Abstract: The present invention is related to a process for selectively transesterifying stanols in mixtures comprising sterols and stanols, and a process for separating sterols from said mixtures. The process of selective transesterification comprises the forming of a reacting mixture by contacting a selective lipase with a reactant mixture comprising sterols and stanols and an ester selected from the group consisting of esters of an organic acid with a short chain aliphatic alcohol. The transetrifying is carried out agitated reactors at pressures below atmospheric pressure and temperatures from 30 to 90° C.Type: GrantFiled: July 26, 2002Date of Patent: August 8, 2006Assignee: Harting, S.A.Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Endre Markovits Schersl, Irene Martinez Basterrechea
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Patent number: 7078544Abstract: A process for producing steryl or stanyl esters, comprises the steps of: a) forming a reacting mixture by contacting a lipase with a reactant mixture wherein the reactant mixture comprise sterols or stanols and one or more esters selected from the group consisting of esters of a fatty acid with a short chain aliphatic alcohol; b) separating the lipase from the reacting mixture to form a reacted mixture; and c) separating steryl or stanyl esters from the reacted mixture. The reaction is carried out in stirred reactors at pressures below atmospheric pressure and temperatures from 30 to 90° C. The separation of esters from the reacted mixtures is carried out by distillation at low pressures. A process for esterifying sterols or stanols comprise forming a reacting mixture by contacting a lipase with a reactant mixture wherein the reactant mixture comprise sterols or stanols and one or more esters selected from the group consisting of esters of a fatty acid with a short chain aliphatic alcohol.Type: GrantFiled: July 26, 2002Date of Patent: July 18, 2006Assignee: Harting, S.A.Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Endre Markovits Schersl, Irene Martinez Basterrechea
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Publication number: 20030109729Abstract: The present invention relates to a fractionation process of the unsaponifiable material derived from black-liquor soaps of the cellulose industry. Through this procedure fractions that essentially contain free sterols, fatty alcohols, sterol esters and fatty alcohol esters respectively are separated. Fractions containing sterols or fatty alcohols can be used as such in the alimentary, cosmetic and pharmaceutical industries or they can be used as raw materials for transforming into other useful products.Type: ApplicationFiled: January 6, 2003Publication date: June 12, 2003Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Endre Markovits Schersl
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Publication number: 20030100044Abstract: The present invention is related to a process for selectively transesterifying stanols in mixtures comprising sterols and stanols, and a process for separating sterols from said mixtures.Type: ApplicationFiled: September 30, 2002Publication date: May 29, 2003Inventors: Miguel Angel Fuenzalida Diaz, Alejandro Markovits Rojas, Endre Markovits Schersl, Irene Martinez Basterrechea