Patents by Inventor Alejandro Mas Monteys

Alejandro Mas Monteys has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Treating Huntington's Disease and Related Disorders
    Publication number: 20230235325
    Abstract: Compositions and methods are provided for the inhibition, treatment and/or prevention of Huntington's disease and related disorders.
    Type: Application
    Filed: October 7, 2022
    Publication date: July 27, 2023
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Shauna Ebanks
  • Compositions and methods for treating Huntington's disease and related disorders
    Patent number: 11473084
    Abstract: Compositions and methods are provided for the inhibition, treatment and/or prevention of Huntington's disease and related disorders.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: October 18, 2022
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Shauna Ebanks
  • Therapeutic for treatment of diseases including the central nervous system
    Patent number: 11155817
    Abstract: The present disclosure provides filler or stuffer sequences, compositions thereof including expression cassettes and vectors, such as viral (e.g., AAV) vectors and methods of delivering a therapeutic agent to a mammal and/or treating a disease.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: October 26, 2021
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Megan S. Keiser
  • Compositions and Methods for Treating Huntington's Disease and Related Disorders
    Publication number: 20190055552
    Abstract: Compositions and methods are provided for the inhibition, treatment and/or prevention of Huntington's disease and related disorders.
    Type: Application
    Filed: October 11, 2016
    Publication date: February 21, 2019
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Shauna Ebanks
  • Promoter compositions
    Patent number: 10105450
    Abstract: An isolated promoter sequence comprising a nucleic acid of between 600 and 1700 nucleotides in length having at least 90% identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 23, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Edgardo Rodriguez, Alejandro Mas Monteys
  • Reduction of off-target RNA interference toxicity
    Patent number: 10093927
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 9, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi McBride, Ryan Boudreau
  • REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY
    Publication number: 20170369877
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Application
    Filed: April 7, 2017
    Publication date: December 28, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi McBride, Ryan Boudreau
  • MODIFIED ADENO-ASSOCIATED VIRUS VECTOR COMPOSITIONS
    Publication number: 20170306355
    Abstract: An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.
    Type: Application
    Filed: July 7, 2017
    Publication date: October 26, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Maria Scheel, Ryan Boudreau, Alejandro Mas Monteys
  • Reduction of off-target RNA interference toxicity
    Patent number: 9650631
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: May 16, 2017
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY
    Publication number: 20170022495
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Application
    Filed: August 27, 2013
    Publication date: January 26, 2017
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • Modified adeno-associated virus vector compositions
    Patent number: 9540659
    Abstract: An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 10, 2017
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Maria Scheel, Ryan Boudreau, Alejandro Mas Monteys
  • Huntington's disease therapeutic compounds
    Patent number: 9523093
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: December 20, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20160230169
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
    Type: Application
    Filed: September 15, 2015
    Publication date: August 11, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Ryan Boudreau
  • HUNTINGTON'S DISEASE THERAPEUTIC COMPOUNDS
    Publication number: 20160060624
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
    Type: Application
    Filed: May 20, 2015
    Publication date: March 3, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys
  • PROMOTER COMPOSITIONS
    Publication number: 20160022837
    Abstract: An isolated promoter sequence comprising a nucleic acid of between 600 and 1700 nucleotides in length having at least 90% identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 28, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Edgardo Rodriguez, Alejandro Mas Monteys
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 9169483
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: October 27, 2015
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Ryan L. Boudreau
  • REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY
    Publication number: 20140303362
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Application
    Filed: August 27, 2013
    Publication date: October 9, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20140163214
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
    Type: Application
    Filed: July 2, 2013
    Publication date: June 12, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Ryan L. Boudreau
  • Reduction of off-target RNA interference toxicity
    Patent number: 8524881
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: September 3, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Jodi L. McBride, Ryan Boudreau
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 8487088
    Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: July 16, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Ryan L. Boudreau