Patents by Inventor Alejandro R. Chade

Alejandro R. Chade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kidney-targeted drug delivery systems
    Patent number: 12667623
    Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and a therapeutic agent is provided.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: June 30, 2026
    Assignee: University of Mississippi Medical Center
    Inventors: Alejandro R. Chade, Gene L. Bidwell, III
  • Molecular-size of elastin-like polypeptide delivery system for therapeutics modulates intrarenal deposition and bioavailability
    Patent number: 11564991
    Abstract: A renal cortex targeting elastin-like polypeptide (ELP), a renal medulla and cortex targeting ELP, and a method of treating a renal disorder are provided. The renal cortex targeting ELP includes up to 95 repeat units having the sequence VPGXG (SEQ ID NO: 1), where X in each of the repeat units is any amino acid except proline. The renal medulla and cortex targeting ELP includes at least 95 repeat units of SEQ ID NO: 1, where X in each of the repeat units is any amino acid except proline. The method of treating a renal disorder includes administering an ELP and a therapeutic drug to a subject in need thereof, where the ELP includes up to 671 repeat units of SEQ ID NO: 1 and X in each of the repeat units is any amino acid except proline.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: January 31, 2023
    Assignee: University of Mississippi Medical Center
    Inventors: Gene L. Bidwell, III, Alejandro R. Chade
  • Molecular-size of elastin-like polypeptide delivery system for therapeutics modulates intrarenal deposition and bioavailability
    Patent number: 11248038
    Abstract: A renal cortex targeting elastin-like polypeptide (ELP), a renal medulla and cortex targeting ELP, and a method of treating a renal disorder are provided. The renal cortex targeting ELP includes up to 95 repeat units having the sequence VPGXG (SEQ ID NO: 1), where X in each of the repeat units is any amino acid except proline. The renal medulla and cortex targeting ELP includes at least 95 repeat units of SEQ ID NO: 1, where X in each of the repeat units is any amino acid except proline. The method of treating a renal disorder includes administering an ELP and a therapeutic drug to a subject in need thereof, where the ELP includes up to 671 repeat units of SEQ ID NO: 1 and X in each of the repeat units is any amino acid except proline.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 15, 2022
    Assignee: University of Mississippi Medical Center
    Inventors: Gene L. Bidwell, III, Alejandro R. Chade
  • Molecular-Size of Elastin-Like Polypeptide Delivery System for Therapeutics Modulates Intrarenal Deposition and Bioavailability
    Publication number: 20200360527
    Abstract: A renal cortex targeting elastin-like polypeptide (ELP), a renal medulla and cortex targeting ELP, and a method of treating a renal disorder are provided. The renal cortex targeting ELP includes up to 95 repeat units having the sequence VPGXG (SEQ ID NO: 1), where X in each of the repeat units is any amino acid except proline. The renal medulla and cortex targeting ELP includes at least 95 repeat units of SEQ ID NO: 1, where X in each of the repeat units is any amino acid except proline. The method of treating a renal disorder includes administering an ELP and a therapeutic drug to a subject in need thereof, where the ELP includes up to 671 repeat units of SEQ ID NO: 1 and X in each of the repeat units is any amino acid except proline.
    Type: Application
    Filed: March 30, 2020
    Publication date: November 19, 2020
    Inventors: Gene L. Bidwell, III, Alejandro R. Chade
  • Molecular-Size of Elastin-Like Polypeptide Delivery System for Therapeutics Modulates Intrarenal Deposition and Bioavailability
    Publication number: 20200317750
    Abstract: A renal cortex targeting elastin-like polypeptide (ELP), a renal medulla and cortex targeting ELP, and a method of treating a renal disorder are provided. The renal cortex targeting ELP includes up to 95 repeat units having the sequence VPGXG (SEQ ID NO: 1), where X in each of the repeat units is any amino acid except proline. The renal medulla and cortex targeting ELP includes at least 95 repeat units of SEQ ID NO: 1, where X in each of the repeat units is any amino acid except proline. The method of treating a renal disorder includes administering an ELP and a therapeutic drug to a subject in need thereof, where the ELP includes up to 671 repeat units of SEQ ID NO: 1 and X in each of the repeat units is any amino acid except proline.
    Type: Application
    Filed: March 30, 2020
    Publication date: October 8, 2020
    Inventors: Gene L. Bidwell, III, Alejandro R. Chade
  • Kidney-Targeted Drug Delivery Systems
    Publication number: 20190314514
    Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and a therapeutic agent is provided.
    Type: Application
    Filed: April 29, 2019
    Publication date: October 17, 2019
    Inventors: Alejandro R. Chade, Gene L. Bidwell, III