Patents by Inventor Alejandro R. Chade, III

Alejandro R. Chade, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kidney-targeted drug delivery systems
    Patent number: 10322189
    Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and/or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: June 18, 2019
    Assignee: University of Mississippi Medical Center
    Inventors: Alejandro R. Chade, III, Gene L. Bidwell, III
  • Kidney-Targeted Drug Delivery Systems
    Publication number: 20180008721
    Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and/or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.
    Type: Application
    Filed: November 12, 2015
    Publication date: January 11, 2018
    Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
    Inventors: Alejandro R. Chade, III, Gene L. Bidwell, III