Abstract: Provided are methods for isolating T-cells with T cell receptors (TCRs) optimized for reactivity to specific peptides and decreased cross-reactivity to non-target peptides. Advantageously, TCRs of the invention can be optimized to target cancer antigens and peptides while having reducing reactivity to healthy cells. Methods of the invention utilize a novel combination of culturing conditions that increase T-cell activation and allow for validation of TCR activity. Culturing conditions of the invention further reduce culturing times generally needed to achieve expanded reactive T-cells. Because of the robust nature of the activation and validation conditions of the present invention, variants of identified TCRs can also be optimized and validated for their response to peptides, including cancer peptides.

Abstract: Provided are methods for isolating T-cells with T cell receptors (TCRs) optimized for reactivity to specific peptides and decreased cross-reactivity to non-target peptides. Advantageously, TCRs of the invention can be optimized to target cancer antigens and peptides while having reducing reactivity to healthy cells. Methods of the invention utilize a novel combination of culturing conditions that increase T-cell activation and allow for validation of TCR activity. Culturing conditions of the invention further reduce culturing times generally needed to achieve expanded reactive T-cells. Because of the robust nature of the activation and validation conditions of the present invention, variants of identified TCRs can also be optimized and validated for their response to peptides, including cancer peptides.

Abstract: Provided are methods for isolating T-cells with T cell receptors (TCRs) optimized for reactivity to specific peptides and decreased cross-reactivity to non-target peptides. Advantageously, TCRs of the invention can be optimized to target cancer antigens and peptides while having reducing reactivity to healthy cells. Methods of the invention utilize a novel combination of culturing conditions that increase T-cell activation and allow for validation of TCR activity. Culturing conditions of the invention further reduce culturing times generally needed to achieve expanded reactive T-cells. Because of the robust nature of the activation and validation conditions of the present invention, variants of identified TCRs can also be optimized and validated for their response to peptides, including cancer peptides.

Abstract: Provided are methods for isolating T-cells with T cell receptors (TCRs) optimized for reactivity to specific peptides and decreased cross-reactivity to non-target peptides. Advantageously, TCRs of the invention can be optimized to target cancer antigens and peptides while having reducing reactivity to healthy cells. Methods of the invention utilize a novel combination of culturing conditions that increase T-cell activation and allow for validation of TCR activity. Culturing conditions of the invention further reduce culturing times generally needed to achieve expanded reactive T-cells. Because of the robust nature of the activation and validation conditions of the present invention, variants of identified TCRs can also be optimized and validated for their response to peptides, including cancer peptides.

Abstract: In order to detect movements of objects and/or living beings in a radio range, which enables easily with a minimum of hardware complexity an automated movement detection based on a Single-Sensor, it is proposed to: Collect as input data for the movement detection based on received radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range a set of “Channel State Information”-values, determine a change in the received radio signals, which are derived from the facts that the movement influences the transmitted radio signal in the radio range based on the collected CSI-values by the indication of a statistical parameter value, and assess on the basis of the statistical parameter value a “chaos index” value until the “chaos index” value in accordance with a threshold check provides a reliable statement.

Abstract: A method, digital tool, device, and system for detecting movements of objects and/or living beings in a radio range, which enables easily with a minimum of hardware complexity an automated movement detection based on a Single-Sensor, is provided. The method includes collecting as input data for the movement detection based on received radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range “Received Signal Strength” values related quantities, determining a change in the received radio signals, which are derived from the facts that the movement influences the transmitted radio signal in the radio range based on the RSS-values related quantities by the indication of a statistical parameter value, and assessing the statistical parameter value until the statistical parameter value in accordance with a threshold check provides a reliable statement for controlling purposes.

Abstract: Applicants have created an improved multi-flavor food and/or beverage dispenser including an improved nozzle for injection of flavored liquids into a base liquid.

Abstract: Applicants have created an improved multi-flavor food and/or beverage dispenser including an improved nozzle for injection of flavored liquids into a base liquid. The apparatuses and systems described herein can be used with different food and beverage products including, but not limited to, frozen carbonated beverages, frozen alcoholic and non-alcoholic beverages, frozen yogurts, frozen ice creams and other dispensable food and beverage products.

Abstract: Applicants have created an improved multi-flavor food and/or beverage dispenser including an improved nozzle for injection of flavored liquids into a base liquid.

Abstract: Applicants have created an improved multi-flavor food and/or beverage dispenser including an improved nozzle for injection of flavored liquids into a base liquid. The apparatuses and systems described herein can be used with different food and beverage products including, but not limited to, frozen carbonated beverages, frozen alcoholic and non-alcoholic beverages, frozen yogurts, frozen ice creams and other dispensable food and beverage products.

Abstract: In order to detect movements of objects and/or living beings in a radio range, which enables easily with a minimum of hardware complexity an automated movement detection based on a Single-Sensor, it is proposed to: Collect as input data for the movement detection based on received radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range a set of “Channel State Information”-values, determine a change in the received radio signals, which are derived from the facts that the movement influences the transmitted radio signal in the radio range based on the collected CSI-values by the indication of a statistical parameter value, and assess on the basis of the statistical parameter value a “chaos index” value until the “chaos index” value in accordance with a threshold check provides a reliable statement.

Abstract: In order to detect movements of objects and/or living beings in a radio range, which enables easily with a minimum of hardware complexity an automated movement detection based on a Single-Sensor, it is proposed to: Collect as input data for the movement detection based on received radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range a set of “Channel State Information”-values, determine a change in the received radio signals, which are derived from the facts that the movement influences the transmitted radio signal in the radio range based on the collected CSI-values by the indication of a statistical parameter value, and assess on the basis of the statistical parameter value a “chaos index” value until the “chaos index” value in accordance with a threshold check provides a reliable statement.

Abstract: A method, digital tool, device, and system for detecting movements of objects and/or living beings in a radio range, which enables easily with a minimum of hardware complexity an automated movement detection based on a Single-Sensor, is provided. The method includes collecting as input data for the movement detection based on received radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range “Received Signal Strength”-values related quantities, determining a change in the received radio signals, which are derived from the facts that the movement influences the transmitted radio signal in the radio range based on the RSS-values related quantities by the indication of a statistical parameter value, and assessing the statistical parameter value until the statistical parameter value in accordance with a threshold check provides a reliable statement for controlling purposes.

Abstract: A method, digital tool, device, and system for detecting movements of objects and/or living beings in a radio range, which enables easily with a minimum of hardware complexity an automated movement detection based on a Single-Sensor, is provided. The method includes collecting as input data for the movement detection based on received radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range “Received Signal Strength” values related quantities, determining a change in the received radio signals, which are derived from the facts that the movement influences the transmitted radio signal in the radio range based on the RSS-values related quantities by the indication of a statistical parameter value, and assessing the statistical parameter value until the statistical parameter value in accordance with a threshold check provides a reliable statement for controlling purposes.

Abstract: The invention relates to a beacon for broadcasting data to a plurality of devices in a certain range comprising—an interface for receiving a signal—a processing unit which is arranged to generate a control signal for an adaptation of a transmission of data depending on the received signal.

Abstract: Applicants have created an improved multi-flavor food and/or beverage dispenser including an improved nozzle for injection of flavored liquids into a base liquid.

Abstract: A method, device, and system for detecting/recognizing in a radio range repetitive motions with at least one motional speed and each at least one repetition, is provided. The method includes the steps of collecting as input data for the repetitive motion detection/recognition based on the reception of quantifiable radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range “Received Signal Strength”-values related quantities or “Channel State Information”-quantities, and determining a pattern in the received radio signals, and accessing the peak value until the peak value in accordance with a threshold check provides a reliable statement, particularly being used for controlling purposes.

Abstract: The disclosure relates to a method for determining an indoor position of a moving object. The method includes using a first location determination method for determining first position data; using at least a second location determination method for determining second position data; and deriving a position of the moving object by combining first and second position data gathered from both systems.

Abstract: An improved frozen product dispenser wherein a product is placed into a cooled hopper and the product is then fed from the hopper into a freezing and dispensing chamber where it is frozen and dispensed.

Abstract: A method, device, and system for detecting/recognizing in a radio range repetitive motions with at least one motional speed and each at least one repetition, is provided. The method includes the steps of collecting as input data for the repetitive motion detection/recognition based on the reception of quantifiable radio signals of an intended or unintended communication between a transmitting radio terminal being mobile or fixed and a receiving local fixed radio device in the radio range “Received Signal Strength”-values related quantities or “Channel State Information”-quantities, and determining a pattern in the received radio signals, and accessing the peak value until the peak value in accordance with a threshold check provides a reliable statement, particularly being used for controlling purposes.