Patents by Inventor Alejandro Ruiz-Valls

Alejandro Ruiz-Valls has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF AN INTEGRATED MICROFLUIDIC CHIP FOR ANALYSIS OF CELL MOTILITY AND PREDICTION AND PROGNOSIS OF PATIENT SURVIVAL
    Publication number: 20240044898
    Abstract: The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.
    Type: Application
    Filed: August 9, 2023
    Publication date: February 8, 2024
    Inventors: Konstantinos Konstantopoulos, Colin Paul, Alfredo Quinones-Hinojosa, Sagar Ramesh Shah, Alejandro Ruiz-Valls, Christopher Yankaskas, Juan Carlos Martinez-Gutierrez, Bin Sheng Wong
  • Use of an integrated microfluidic chip for analysis of cell motility and prediction and prognosis of patient survival
    Patent number: 11747338
    Abstract: The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: September 5, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Konstantinos Konstantopoulos, Colin Paul, Alfredo Quinones-Hinojosa, Sagar Ramesh Shah, Alejandro Ruiz-Valls, Christopher Yankaskas, Juan Carlos Martinez-Gutierrez, Bin Sheng Wong
  • SELF-ASSEMBLING VERTEPORFIN AMPHIPHILES (SAVA) FOR LOCAL CANCER THERAPY
    Publication number: 20220062432
    Abstract: The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 3, 2022
    Inventors: Sagar Ramesh Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa
  • SELF-ASSEMBLING VERTEPORFIN AMPHIPHILES (SAVA) FOR LOCAL CANCER THERAPY
    Publication number: 20200384116
    Abstract: The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.
    Type: Application
    Filed: January 10, 2020
    Publication date: December 10, 2020
    Inventors: Sagar Ramesh Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa
  • USE OF AN INTEGRATED MICROFLUIDIC CHIP FOR ANALYSIS OF CELL MOTILITY AND PREDICTION AND PROGNOSIS OF PATIENT SURVIVAL
    Publication number: 20200249232
    Abstract: The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.
    Type: Application
    Filed: December 2, 2016
    Publication date: August 6, 2020
    Inventors: Konstantinos Konstantopoulos, Colin Paul, Alfredo Quinones-Hinojosa, Sagar Ramesh Shah, Alejandro Ruiz-Valls, Christopher Yankaskas, Juan Carlos Martinez-Gutierrez, Bin Sheng Wong
  • SELF-ASSEMBLING VERTEPORFIN AMPHIPHILES (SAVA) FOR LOCAL CANCER THERAPY
    Publication number: 20190117786
    Abstract: The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.
    Type: Application
    Filed: January 11, 2017
    Publication date: April 25, 2019
    Inventors: Sagar Ramesh Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa