Abstract: The present invention is directed to a method of multi-motion compensation for high-quality cone-beam CT of the head. A multi-stage approach is incorporated that includes a pre-conditioning stage in which an initial estimation of the motion trajectory is obtained with 3D-2D registration using the motion-contaminated CBCT and projection data. In the present invention, the motion-contaminated CBCT is used as a basis for 3D-2D registration in the pre-conditioning stage to capture large amplitude, rapid movements of the head and provide better initialization of the autofocus solution.

Abstract: Techniques for computed tomography (CT) image reconstruction are presented. The techniques can include acquiring, by a detector grid of a computed tomography system, detector signals for a location within an object of interest representing a voxel, where each detector signal of a plurality of the detector signals is obtained from an x-ray passing through the location at a different viewing angle; reconstructing a three-dimensional representation of at least the object of interest, the three-dimensional representation comprising the voxel, where the reconstructing comprises computationally perturbing a location of each detector signal of the plurality of detector signals within the detector grid, where the computationally perturbing corresponds to randomly perturbing a location of the x-ray within the voxel; and outputting the three-dimensional representation.