Patents by Inventor ALEJANDRO VILLAGRA

ALEJANDRO VILLAGRA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STAT-ACTIVATED MACROPHAGES, COMPOSITIONS, AND USES THEREOF
    Publication number: 20230405118
    Abstract: The present disclosure provides signal transducer and activator of transcription (STAT)-activated macrophages, compositions comprising STAT-activated macrophages, methods of making STAT-activated macrophages, and methods of treating diseases, e.g., cancer, by administering a therapeutically effective amount of STAT-activated macrophages.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 21, 2023
    Applicant: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION
    Inventors: Alejandro VILLAGRA, Satish NOONEPALLE, Maria del Mar Gracia HERNANDEZ
  • COMPOSITIONS FOR AND METHODS OF TREATING CANCER
    Publication number: 20230391868
    Abstract: Disclosed herein are compositions comprising HDAC6 inhibitors and CD47 inhibitors and methods of treating cancer using such compositions.
    Type: Application
    Filed: April 7, 2023
    Publication date: December 7, 2023
    Inventors: Alejandro Villagra, Maria del Mar Gracia Hernandez
  • SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS
    Publication number: 20230250054
    Abstract: The present disclosure provides methods, pharmaceutical compositions, and kits comprising histone deacetylase (HD AC) inhibitors of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, L1, L2, m, n, p, X, Y, and Z are as defined in the specification, including methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy in a subject.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 10, 2023
    Inventors: Sida SHEN, Alejandro VILLAGRA, Alan KOZIKOWSKI
  • HDAC6-ACTIVATED MACROPHAGES, COMPOSITIONS, AND USES THEREOF
    Publication number: 20220401474
    Abstract: The present disclosure provides histone deacetylase 6 (HDAC6)-activated macrophages, compositions comprising HDAC6-activated macrophages, methods of making HDAC6-activated macrophages, and methods of treating diseases, e.g., cancer, by administering a therapeutically effective amount of HDAC6-activated macrophages.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 22, 2022
    Inventors: Alejandro VILLAGRA, Nima AGHDAM, Satish NOONEPALLE
  • Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors
    Patent number: 11472780
    Abstract: The present disclosure provides compounds represented by Formula (I): and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 18, 2022
    Assignees: The George Washington University, The Board of Trustees ofthe University of Illinois
    Inventors: Alejandro Villagra, Alan P. Kozikowski, Sida Shen
  • ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS
    Publication number: 20220153709
    Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
    Type: Application
    Filed: February 1, 2022
    Publication date: May 19, 2022
    Applicants: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, The Board of Trustees of the University of Illinois
    Inventors: Alejandro VILLAGRA, Alan P. KOZIKOWSKI, Sida SHEN
  • Isoxazole Hydroxamic Acids As Histone Deacetylase 6 Inhibitors
    Publication number: 20200115350
    Abstract: The present disclosure provides compounds represented by Formula (I): and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 16, 2020
    Inventors: ALEJANDRO VILLAGRA, Alan P. KOZIKOWSKI, Sida SHEN