Abstract: Described herein is a therapeutic method that specifically addresses tumor-infiltrated regulatory T cells (Tregs) with minimal impact on the peripheral Tregs.

Abstract: The invention relates to an ear catheter for insertion into the eustachian tube with a first tube as catheter tube (3) provided with at least one first lumen as injection duct (3A) for the application of a liquid/fluid, at least one second lumen as pressure relief lumen (3B) for pressure relief and a self-expandable sealing element (2) for the occlusion of the eustachian tube, as well as an insertion aid comprising a headpiece, a middle piece and an end piece, wherein the insertion aid consists of a biocompatible polymer, and with at least one separator line extending at least through each of the middle piece and the end piece, along which the insertion aid can be unfolded or split open. The insertion aid proposed by the invention can thus be removed from a catheter even if the catheter ends are blocked.

Abstract: A method is disclosed. The method includes receiving, by one or more processors, a plurality of data values generated by one or more functional apparatuses. The processors group sets of data values from the plurality of data values. The processors, for each set of data values, determine a number of data values that pass a first predetermined threshold value, create a data point comprising the number of data values in the set of data values, a start time, and an end time, and store the data point when the number of data values in the data point pass a second predetermined threshold value. The processors analyze a group of data points created in step c) to determine if a total number of data values in the group of data points pass a criteria. The processors perform additional processing, if the total number of data values passes the criteria.