Abstract: The invention concerns a method for producing a beverage by dissolution of at least one soluble beverage powder with water in a beverage preparation apparatus, said apparatus comprising:—at least one chamber (1a, 1b) configured for receiving and mixing at least one soluble beverage powder with water to prepare beverage and for dispensing beverage to a drinking receptacle receiving area (10), and—a nozzle (4) for delivering a jet of water to the drinking receptacle receiving area (10), and said method comprising the steps of: a) preparing a beverage with said at least one chamber and dispensing said beverage inside a drinking receptacle (9) at the receiving area (10), the beverage forming visual layers inside the drinking receptacle, wherein said method comprises the step b) of jetting water through the nozzle (4) inside the drinking receptacle (9) at the receiving area after step a).

Abstract: The invention concerns a beverage preparation apparatus (100), said apparatus comprising at least one chamber (1) for receiving and mixing water and at least one soluble beverage ingredient, said chamber comprising: —a lateral side wall (11) defining an internal mixing volume, —a bottom wall (12) comprising a beverage outlet (3), —at least one water supply device (2) configured for creating a jet of water (21) and orienting said jet of water inside the chamber, —at least one rotating device (4) configured to rotate around a rotational axis inside the mixing chamber, said rotating device comprising blades (41), wherein the blades of the rotating device are freely rotatable around the rotational axis, and wherein the jet of water introduced in the chamber is oriented to hit the blades of the rotating device and actuate the rotation of the rotating device around the rotational axis.

Abstract: The invention concerns a method for producing a beverage by dissolution of soluble beverage powder with water in a beverage preparation apparatus, —said apparatus comprising at least one chamber (1) for receiving and mixing a dose of soluble beverage powder with water, said chamber comprising : —an opened top to receive the dose of soluble beverage powder, and —a lateral side wall (11) said lateral side wall comprising a water inlet (2), and —a bottom wall (12), said bottom wall comprising a beverage outlet conduit (3), and —said method comprising the steps of: a) —introducing water through the water inlet (2) to wet the internal surface of the funnel of the bottom wall, then b) —stopping the introduction of water, then c) —introducing the dose of soluble beverage powder in the chamber, then d) —introducing water in the chamber to dissolve the powder.

Abstract: A system is provided having a guide member with features, such as grid and axes, which spatially correlate to tissue with a lesion adjacent the guide member, and a template device upon the tissue aligned with the features having a first aperture over the guide member, and a second aperture over the tissue with the lesion. A microscope captures one or more images of the tissue via the second aperture at one or more locations each spatially correlated with a location selected or being mapped along the guide member in the first aperture. Prior to imaging and template device placement, marks are recorded along the guide member when, as part of a tracing sheet, it is positioned in a folded state over the lesion. When returned to an unfolded state, the guide member once removed from the tracing guide sheet is positioned for use with the template device and microscope.

Abstract: Methods of predicting whether or not a tumor will be responsive to IP6 treatment, methods of treating patients with cancer using IP6, methods of predicting the progression of a disease, and kits that facilitate these methods are disclosed.

Abstract: The present invention relates to methods of selectively treating a patient with skin squamous cell carcinoma are disclosed. Specifically, the methods comprise assessing whether or not the tumor will be responsive to IP6 treatment by using reduced INPP5A expression level as an indicator. The present invention further provides methods of assessing the progression of the disease, and kits that facilitate these methods as disclosed.

Abstract: A system is provided having a guide member with features, such as grid and axes, which spatially correlate to tissue with a lesion adjacent the guide member, and a template device upon the tissue aligned with the features having a first aperture over the guide member, and a second aperture over the tissue with the lesion. A microscope captures one or more images of the tissue via the second aperture at one or more locations each spatially correlated with a location selected or being mapped along the guide member in the first aperture. Prior to imaging and template device placement, marks are recorded along the guide member when part of a tracing sheet is positioned in a folded state over the lesion to establish spatial correlation of the features of the guide member to the lesion when in an unfolded state and positioned for use with the template device and microscope.

Abstract: Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein.

Abstract: Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein.