Patents by Inventor Aleksander Resman

Aleksander Resman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100305087
    Abstract: A combination preparation comprising an active pharmaceutical ingredient (API) and a pharmaceutically acceptable solid support, wherein said solid support is in a water-insoluble particulate form and comprises a material selected from silicic acid, aluminum hydroxide and titanium hydroxide is disclosed. The API is a compound having both, at least one hydrophobic structural moiety causing the API to have a low solubility in water or in an aqueous solution, and multiple hydrophilic groups arranged to form multiple intermolecular interactions to the solid support involving polar or ionic or hydrogen bonding. The hydrophilic groups of the API are independently equal or different and comprise at least one of the groups consisting of OH- and halogen-groups. The API is bound to the solid support by adsorption, and a major proportion of said API is in an amorphous state. Related pharmaceuticals and methods of preparation also are disclosed.
    Type: Application
    Filed: December 18, 2008
    Publication date: December 2, 2010
    Applicant: Lek Pharmaceuticals d.d.
    Inventors: Rok Grahek, Aleksander Resman, Andrej Bastarda, Martin Crnugelj
  • Publication number: 20060083759
    Abstract: The invention discloses a method of a physical pre-treatment of an active substance, which modifies technologically important physical properties of the active substance so as to enable the manufacture of a formulation having a more stable release profile of the active substance over the whole shelf life of the medicine than the profile would be with the same composition, but without pre-treatment.
    Type: Application
    Filed: July 15, 2002
    Publication date: April 20, 2006
    Inventors: Aleksander Resman, Darja Fercej-Temeljotov, Vlasta Humar, Marko Opresnik
  • Patent number: 6984399
    Abstract: The present invention relates to a novel solid pharmaceutical formulation containing lovastatin and simvastatin, respectively, with a particle size D(0.9) between 15 and 100 ?m and a specific particle surface area between 1 and 4 m2/g, and to the process for its preparation. The present invention also relates to the method for production of lovastatin and simvastatin with the size of crystals which are suitable for the preparation of the pharmaceutical formulation of the present invention. The novel solid pharmaceutical formulation is useful for treating hypercholesterolemia and hyperlipidemia.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: January 10, 2006
    Assignee: Lek Pharmaceuticals d.d.
    Inventors: Zlatko Pflaum, Mateja Salobir, Zdenka Jerala, Aleksander Resman
  • Publication number: 20040138295
    Abstract: The present invention relates to a novel solid pharmaceutical formulation containing lovastatin and simvastatin, respectively, with a particle size D(0.9) between 15 and 100 &mgr;m and a specific particle surface area between 1 and 4 m2/g, and to the process for its preparation. The present invention also relates to the method for production of lovastatin and simvastatin with the size of crystals which are suitable for the preparation of the pharmaceutical formulation of the present invention. The novel solid pharmaceutical formulation is useful for treating hypercholesterolemia and hyperlipidemia.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 15, 2004
    Applicant: Lek Pharmaceuticals d.d.
    Inventors: Zlatko Pflaum, Mateja Salobir, Zdenka Jerala, Aleksander Resman
  • Patent number: 6696086
    Abstract: The present invention relates to a novel solid pharmaceutical formulation containing lovastatin and simvastatin, respectively, with a particle size D(0.9) between 15 and 100 &mgr;m and a specific particle surface area between 1 and 4 m2/g, and to the process for its preparation. The present invention also relates to the method for production of lovastatin and simvastatin with the size of crystals which are suitable for the preparation of the pharmaceutical formulation of the present invention. The novel solid pharmaceutical formulation is useful for treating hypercholesterolemia and hyperlipidemia.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: February 24, 2004
    Assignee: Lek Pharmaceuticals d.d.
    Inventors: Zlatko Pflaum, Mateja Salobir, Zdenka Jerala, Aleksander Resman