Patents by Inventor Aleksandr Vladimirovich KARABELSKII

Aleksandr Vladimirovich KARABELSKII has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOLATED MODIFIED VP1 CAPSID PROTEIN OF AAV5
    Publication number: 20220306696
    Abstract: This application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to an isolated altered VP1 protein of adeno-associated virus serotype 5 (AAVS) capsid comprising one or more amino acid substitutions as compared to the VP1 protein of wild-type AAVS capsid, which increase transduction efficiency, as well as to a capsid and a vector based thereon.
    Type: Application
    Filed: August 21, 2020
    Publication date: September 29, 2022
    Inventors: Anna Nikolaevna STRELKOVA, Aleksandr Vladimirovich KARABELSKII, Dmitrij Aleksandrovich MADERA, Mariya Pavlovna PEREPELKINA, Elena Victorovna IURLOVA, Pavel Mikhailovich GERSHOVICH, Alexandr Vladimirovich PROKOFYEV, Dmitry Valentinovich MOROZOV
  • Trispecific antibodies against IL-17A, IL-17F and other pro-inflammatory molecule
    Patent number: 11453717
    Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNF?) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: September 27, 2022
    Inventors: Dmitry Valentinovich Morozov, Andrei Borisovich Ulitin, Ekaterina Sergeevna Zubareva, Iakov Iurevich Ustiugov, Aleksandr Vladimirovich Karabelskii, Dmitry Valeryevich Korzhavin, Tatiana Veniaminovna Chernovskaya, Aleksandr Valerevich Grachev, Yury Ivanovich Basovskiy, Ekaterina Aleksandrovna Lomkova, Veronika Sergeevna Usatova, Aleksei Aleksandrovich Aleksandrov, Elena Leonidovna Morozova, Roman Alekseevich Ivanov, Pavel Andreevich Iakovlev
  • ALTERNATIVE INTRACELLULAR SIGNALLING DOMAIN OF A CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20220127329
    Abstract: The present invention relates to the field of biotechnology, specifically to an isolated alternative intracellular signalling domain of a chimeric antigen receptor (CAR) and to a chimeric antigen receptor (CAR) comprising, said signalling domain. The invention also relates to a nucleic acid coding an alternative intracellular signalling domain of a chimeric antigen receptor, and to a nucleic acid coding a chimeric antigen receptor with the above-mentioned signalling domain, to an expression vector, to a delivery vector, and also a genetically modified cell which comprises the above-mentioned chimeric antigen receptor, and to a method for producing said cell.
    Type: Application
    Filed: March 13, 2020
    Publication date: April 28, 2022
    Inventors: Pavel Mikhailovich GERSHOVICH, Aleksandr Vladimirovich KARABELSKII, Andrei Borisovich ULITIN, Dmitrij Aleksandrovich MADERA, Roman Alexeevich IVANOV, Dmitry Valentinovich MOROZOV
  • PaCas9 nuclease
    Publication number: 20220064612
    Abstract: The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector, which comprise said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding said nuclease.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 3, 2022
    Inventors: Dmitriy Aleksandrovich MADERA, Aleksandr Vladimirovich KARABELSKII, Roman Alekseevich IVANOV, Dmitry Valentinovich MOROZOV, Konstantin Viktorovich SEVERINOV, Sergey Anatolevich SHMAKOV, Dmitrii Aleksandrovich SUTORMIN, Georgii Evgenevich POBEGALOV, Aleksandra Andreevna VASILEVA, Polina Anatolevna SELKOVA, Anatolii Nikolaevich ARSENIEV, Tatyana Igorevna ZYUBKO, Iana Vitalevna FEDOROVA
  • TRISPECIFIC ANTIBODIES AGAINST IL-17A, IL-17F AND OTHER PRO-INFLAMMATORY MOLECULE
    Publication number: 20210332120
    Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNF?) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.
    Type: Application
    Filed: December 2, 2016
    Publication date: October 28, 2021
    Inventors: Dmitry Valentinovich MOROZOV, Andrei Borisovich ULITIN, Ekaterina Sergeevna ZUBAREVA, Iakov Iurevich USTIUGOV, Aleksandr Vladimirovich KARABELSKII, Dmitry Valeryevich KORZHAVIN, Tatiana Veniaminovna CHERNOVSKAYA, Aleksandr Valerevich GRACHEV, Yury Ivanovich BASOVSKIY, Ekaterina Aleksandrovna LOMKOVA, Veronika Sergeevna USATOVA, Aleksei Aleksandrovich ALEKSANDROV, Elena Leonidovna MOROZOVA, Roman Alekseevich IVANOV, Pavel Andreevich IAKOVLEV