Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.

Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for supporting components of an implantable medical device. The apparatuses, systems, and methods may include a first electrode and a second electrode and a scaffold assembly configured to support the first electrode and the second electrode.

Abstract: A medical device includes: a case at least a portion of which functions as a first electrode; a second electrode disposed in a header coupled to the case; a core assembly, the core assembly including operational circuitry enclosed within a core assembly housing, wherein the case includes the core assembly housing; and a battery assembly, the battery assembly including a battery enclosed within a battery housing, where the case further comprises the battery housing; where the operational circuitry is configured to drive a regulated voltage onto the case.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for supporting components of an implantable medical device. The apparatuses, systems, and methods may include a first electrode and a second electrode and a scaffold assembly configured to support the first electrode and the second electrode.

Abstract: Various embodiment disclosed herein include a method for monitoring serum potassium in a patient. The method can include gathering cardiac electrogram data from the patient using two or more electrodes, separating the cardiac electrogram data into discrete subunits including a T-wave, aligning T-waves to create aligned discrete subunits, averaging the aligned discrete subunits to generate an average T-wave for the cardiac electrogram data, and determining a serum potassium value using the average T-wave for the cardiac electrogram data and a predetermined model relating T-wave values with serum potassium magnitudes.

Abstract: A medical device includes: a case at least a portion of which functions as a first electrode; a second electrode disposed in a header coupled to the case; a core assembly, the core assembly including operational circuitry enclosed within a core assembly housing, wherein the case includes the core assembly housing; and a battery assembly, the battery assembly including a battery enclosed within a battery housing, where the case further comprises the battery housing; where the operational circuitry is configured to drive a regulated voltage onto the case.

Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.

Abstract: A medical device configured to be adhesively coupled to an external surface of a subject, and to facilitate physiological monitoring of the subject, includes: a first portion having a housing that at least partially encloses an interior chamber and has a grip portion that has a peanut-like shape; and a second portion including a flexible patch configured to facilitate operably coupling the first portion to the subject. The flexible patch includes third and fourth sensor connections configured to operably interface with the first and second sensor connections, respectively; first and second sensing elements; and a flexible circuit assembly configured to electrically couple the third sensor connection to the first sensing element and the fourth sensor connection to the second sensing element. An adhesive assembly is configured to couple the first portion to the second portion, and includes conductive adhesive portions.

Abstract: A medical device includes: a case at least a portion of which functions as a first electrode; a second electrode disposed in a header coupled to the case; a core assembly, the core assembly including operational circuitry enclosed within a core assembly housing, wherein the case includes the core assembly housing; and a battery assembly, the battery assembly including a battery enclosed within a battery housing, where the case further comprises the battery housing; where the operational circuitry is configured to drive a regulated voltage onto the case.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.

Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.

Abstract: Embodiments herein relate to a method for treating a cancerous tumor located within a subject. The method can include applying one or more electric fields at or near a site of the cancerous tumor, where the cancerous tumor can include a cancerous cell population. The one or more applied electric fields are effective to delay mitosis and cause mitotic synchronization within a proportion of the cancerous cell population. The method can include removing the one or more electric fields to allow mitosis to proceed within the cancerous cell population. The method can include administering a chemotherapeutic agent to the subject after the one or more electric fields have been removed. Other embodiments are also included herein.

Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.

Abstract: Various embodiment disclosed herein include a method for monitoring serum potassium in a patient. The method can include gathering cardiac electrogram data from the patient using two or more electrodes, separating the cardiac electrogram data into discrete subunits including a T-wave, aligning T-waves to create aligned discrete subunits, averaging the aligned discrete subunits to generate an average T-wave for the cardiac electrogram data, and determining a serum potassium value using the average T-wave for the cardiac electrogram data and a predetermined model relating T-wave values with serum potassium magnitudes.