Patents by Inventor Aleksandra Michalowski

Aleksandra Michalowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene expression signatures of neoplasm responsiveness to therapy
    Patent number: 9670549
    Abstract: Gene signatures for determining whether a neoplasm (such as a multiple myeloma neoplasm) is sensitive to mTORi/HDACi combination therapy and/or for determining the prognosis of a neoplasm in a subject are described. Some embodiments include determining whether a neoplasm is sensitive to mTORi/HDACi combination therapy by predicting whether mTORi/HDACi combination therapy will successfully treat the neoplasm, for example increasing survival of the subject with the neoplasm. In some embodiments, determining the prognosis includes predicting the outcome (such as chance of survival) of the subject with a neoplasm. Also disclosed are reagents, for example arrays, for use with the disclosed methods, as well as computer implementation of the disclosed methods.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: June 6, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Beverly A. Mock, John K. Simmons, Aleksandra Michalowski, Jyoti Patel
  • GENE EXPRESSION SIGNATURES OF NEOPLASM RESPONSIVENESS TO THERAPY
    Publication number: 20140357660
    Abstract: Gene signatures for determining whether a neoplasm (such as a multiple myeloma neoplasm) is sensitive to mTORi/HDACi combination therapy and/or for determining the prognosis of a neoplasm in a subject are described. Some embodiments include determining whether a neoplasm is sensitive to mTORi/HDACi combination therapy by predicting whether mTORi/HDACi combination therapy will successfully treat the neoplasm, for example increasing survival of the subject with the neoplasm. In some embodiments, determining the prognosis includes predicting the outcome (such as chance of survival) of the subject with a neoplasm. Also disclosed are reagents, for example arrays, for use with the disclosed methods, as well as computer implementation of the disclosed methods.
    Type: Application
    Filed: November 12, 2012
    Publication date: December 4, 2014
    Inventors: Beverly A. Mock, John K. Simmons, Aleksandra Michalowski, Jyoti Patel