Patents by Inventor Aleksandra Yurievna Skorokhodova

Aleksandra Yurievna Skorokhodova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for constructing an operon containing translationally coupled genes
    Patent number: 8394610
    Abstract: The present invention provides a method for constructing recombinant translationally coupled operons, a method for producing useful metabolites using the bacterium containing the coupled operons, and a method for monitoring gene expression.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: March 12, 2013
    Assignee: Ajinomoto Co., Inc.
    Inventors: Andrey Yurievich Gulevich, Aleksandra Yurievna Skorokhodova, Vladimir Yurievich Ermishev, Natalya Igorevna Minaeva, Danila Vadimovich Zimenkov, Aleksandr Aleksandrovich Krylov, Irina Vladimirovna Biryukova, Sergei Vladimirovich Mashko
  • Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA
    Patent number: 8227214
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: July 24, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, legal representative, Takuji Ueda
  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the gene
    Patent number: 8187850
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ybiV gene.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: May 29, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremet'eva, Aleksandra Yurievna Skorokhodova, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, legal representative
  • METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA
    Publication number: 20120070865
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 22, 2012
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, Takuji Ueda
  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmACDFH-fimZ cluster or the fimZ gene
    Patent number: 8114639
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: February 14, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Vera Georgievna Doroshenko, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA
    Patent number: 8088606
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: January 3, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Vitaly Grigorievich Paraskevov, Takuji Ueda
  • Method for producing a lower alkyl ester of ?-L-aspartyl-L-phenylalanine
    Patent number: 7935506
    Abstract: A method for producing lower alkyl ester of ?-L-aspartyl-L-phenylalanine by cultivating a recombinant Escherichia coli bacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L-phenylalanine in the medium and synthesizing lower alkyl ester of ?-L-aspartyl-L-phenylalanine from the aspartic acid or its derivative and the obtained L-phenylalanine.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: May 3, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Maria Viacheslavovna Vitushkina, Vitaliy Arkadyevich Livshits, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Irina Vladimirovna Biryukova, Zhanna Iosifovna Katashkina, Aleksandra Yurievna Skorokhodova, Alla Valentinovna Belareva
  • Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the gene
    Patent number: 7919282
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the cpxR gene.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: April 5, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Tatyana Viktorovna Leonova
  • Method for producing an L-amino acid using a bacterium of the family by inactivating a gene encoding a toxin of a bacterial toxin-antitoxin pair
    Patent number: 7855060
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea, wherein said bacterium has attenuated expression of a gene encoding a toxin of a bacterial toxin-antitoxin pair.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: December 21, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremeteva, Aleksandra Yurievna Skorokhodova, Vitaly Grigorievich Paraskevov
  • METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA
    Publication number: 20100311129
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Application
    Filed: August 18, 2010
    Publication date: December 9, 2010
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Vitaly Grigorievich Paraskevov, Takuji Ueda
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family With Attenuated Expression of the ybiV Gene
    Publication number: 20100279362
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ybiV gene.
    Type: Application
    Filed: January 30, 2008
    Publication date: November 4, 2010
    Inventors: Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremet'eva, Aleksandra Yurievna Skorokhodova, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov
  • Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the ydiN gene or the ydiB gene or combination thereof
    Patent number: 7820415
    Abstract: The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ydiN gene, the ydiB gene, or both.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: October 26, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Andrey Yurievich Gulevich, Tatyana Aleksandrovna Gaydenko, Vladimir Yurievich Ermishev, Aleksandra Yurievna Skorokhodova, Irina Vladimirovna Biryukova, Sergei Vladimirovich Mashko
  • Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA
    Patent number: 7803584
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: September 28, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, legal representative, Takuji Ueda
  • Method for producing L-amino acids using bacteria belonging to the genus escherichia
    Publication number: 20100099153
    Abstract: A method for producing lower alkyl ester of ?-L-aspartyl-L-phenylalanine by cultivating a recombinant Escherichia coli bacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L-phenylalanine in the medium and synthesizing lower alkyl ester of ?-L-aspartyl-L-phenylalanine from the aspartic acid or its derivative and the obtained L-phenylalanine.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 22, 2010
    Applicant: Ajinomoto Co., Inc.
    Inventors: Maria Viacheslavovna Vitushkina, Vitaliy Arkadyevich Livshits, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Irina Vladimirovna Biryukova, Zhanna Iosifovna Katashkina, Aleksandra Yurievna Skorokhodova, Alla Valentinovna Belareva
  • bacteria transformed with the yddG gene to enhance L-amino acid producing activity
    Patent number: 7666655
    Abstract: The present invention relates to a method for producing L-amino acid, such as L-phenylalanine and L-tryptophan, is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yddG gene from Escherichia coli, wherein said protein has an activity to make said bacterium resistant to L-phenylalanine, a phenylalanine analogue, or a tryptophan analogue. The present invention further relates to a method for producing lower alkyl ester of ?-L-aspartyl-L-phenylalanine.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: February 23, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Maria Viacheslavovna Vitushkina, Vitaliy Arkadyevich Livshits, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Irina Vladimirovna Biryukova, Zhanna Iosifovna Katashkina, Aleksandra Yurievna Skorokhodova, Alla Valentinovna Belareva
  • Method for producing an L-amino acid using a bacterium with an optimized level of gene expression
    Patent number: 7604979
    Abstract: A method is provided for obtaining an L-amino acid or nucleic acid-producing bacterium belonging to the genus Escherichia with an optimized level of expression of the gene which influences the distribution of carbon flow, such as the sucAB genes, comprising introducing into the chromosome of the bacterium a set of in vitro constructed DNA fragments which contain regulatory elements for gene expression instead of the native elements of the regulatory region of the gene, and selecting the colonies with increased L-amino acid productivity. Also, a method is provided for producing an L-amino acid, such as L-glutamic acid, L-proline, L-arginine, L-glutamine, L-leucine, using the bacterium with an optimized level of expression of the sucAB gene.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: October 20, 2009
    Assignee: Ajinomoto Co., Inc.
    Inventors: Joanna Yosifovna Katashkina, Maria Grigorievna Lunts, Vera Georgievna Doroshenko, Svetlana Aleksandrovna Fomina, Aleksandra Yurievna Skorokhodova, Lirina Valerievna Ivanovskaya, Sergei Vladimirovich Mashko
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family With Attenuated Expression of the cpxR Gene
    Publication number: 20090239267
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the cpxR gene.
    Type: Application
    Filed: January 22, 2008
    Publication date: September 24, 2009
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Tatyana Viktorovna Leonova
  • METHOD FOR CONSTRUCTING AN OPERON CONTAINING TRANSLATIONALLY COUPLED GENES
    Publication number: 20090226919
    Abstract: The present invention provides a method for constructing recombinant translationally coupled operons, a method for producing useful metabolites using the bacterium containing the coupled operons, and a method for monitoring gene expression.
    Type: Application
    Filed: February 19, 2009
    Publication date: September 10, 2009
    Inventors: Andrey Yurievich Gulevich, Aleksandra Yurievna Skorokhodova, Vladimir Yurievich Ermishev, Natalya Igorevna Minaeva, Danila Vadimovich Zimenkov, Aleksandr Aleksandrovich Krylov, Irina Vladimirovna Biryukova, Sergei Vladimirovich Mashko
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family With Enhanced Expression of the fucPIKUR Operon
    Publication number: 20090209011
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to enhance expression of at least one gene of the fucPIKUR operon.
    Type: Application
    Filed: December 7, 2007
    Publication date: August 20, 2009
    Inventors: Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Marina Evgenievna Sheremet'eva, Aleksandra Yurievna Skorokhodova, Vitaly Grigorievich Paraskevov
  • METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE ydiN GENE OR THE ydiB GENE OR COMBINATION THEREOF
    Publication number: 20090191601
    Abstract: The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ydiN gene, the ydiB gene, or both.
    Type: Application
    Filed: February 17, 2009
    Publication date: July 30, 2009
    Inventors: Andrey Yurievich Gulevich, Tatyana Aleksandrovna Gaydenko, Vladimir Yurievich Ermishev, Aleksandra Yurievna Skorokhodova, Irina Vladimirovna Biryukova, Sergei Vladimirovich Mashko