Patents by Inventor Aleksey Lomakin

Aleksey Lomakin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKER TEST FOR ACUTE CORONARY SYNDROME
    Publication number: 20170004276
    Abstract: The present invention relates to biomarker signatures and associated methods for identifying patients that are not likely to manifest significant coronary artery disease. It is based, at least in part, on a study performed on serum samples of 239 patients with clinical symptoms of cardiac distress, some of whom required invasive intervention (stent placement or bypass graft surgery). A set of biomarkers was identified as exhibiting different levels of expression in subjects that did, or did not, require invasive intervention. Further, an algorithm was developed which, using serum levels of these biomarkers, assigned a score to a given patient that was indicative of whether that patient required invasive intervention.
    Type: Application
    Filed: September 14, 2016
    Publication date: January 5, 2017
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Prevencio, Inc.
    Inventors: William A. LaFramboise, Robert V. Masterson, Oscar C. Marroquin, Dennis M. McNamara, Suresh R. Mulukutla, Aleksey Lomakin
  • BIOMARKER TEST FOR ACUTE CORONARY SYNDROME
    Publication number: 20140342923
    Abstract: The present invention relates to biomarker signatures and associated methods for identifying patients that are not likely to manifest significant coronary artery disease. It is based, at least in part, on a study performed on serum samples of 239 patients with clinical symptoms of cardiac distress, some of whom required invasive intervention (stent placement or bypass graft surgery). A set of biomarkers was identified as exhibiting different levels of expression in subjects that did, or did not, require invasive intervention. Further, an algorithm was developed which, using serum levels of these biomarkers, assigned a score to a given patient that was indicative of whether that patient required invasive intervention.
    Type: Application
    Filed: June 5, 2013
    Publication date: November 20, 2014
    Inventors: William A. LAFramboise, Masterson Robert V., Oscar C. Marroquin, Dennis M. McNamara, Suresh R. Mulukutla, Aleksey Lomakin
  • Molecular tweezers for the treatment of amyloid-related diseases
    Patent number: 8791092
    Abstract: This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: July 29, 2014
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs, Massachusetts Institute of Technology, Universitat Duisburg-Essen
    Inventors: Gal Bitan, Akila Shanmugam, Aleksey Lomakin, Thomas Schrader, Frank Gerrit Klarner, Peter Talbiersky, Jolanta Polkowska, Frank Bastkowski, Sharmistha Sinha, Sally Frautschy
  • MOLECULAR TWEEZERS FOR THE TREATMENT OF AMYLOID-RELATED DISEASES
    Publication number: 20120108548
    Abstract: This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.
    Type: Application
    Filed: March 5, 2010
    Publication date: May 3, 2012
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITÄT DUISBURG-ESSEN, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Gal Bitan, Akila Shanmugam, Aleksey Lomakin, Thomas Schrader, Frank Gerrit Klarner, Peter Talbiersky, Jolanta Polkowska, Frank Bastkowski, Sharmistha Sinha, Sally Frautschy