Patents by Inventor Alena Rudolph

Alena Rudolph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO-(p-tolyl) groups
    Patent number: 9850254
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: December 26, 2017
    Assignee: Sandoz AG
    Inventors: Fabio E. S. Souza, Alena Rudolph, Dino Alberico, Robert Jordan, Ming Pan, Boris Gorin
  • Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
    Patent number: 9695187
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: July 4, 2017
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN
    Publication number: 20160152631
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10 , R11 , R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 2, 2016
    Inventors: Fabio E.S. SOUZA, Alena RUDOLPH, Ming PAN, Boris GORIN, Teng Ko NGOOI, Jason A. BEXRUD, Ricardo ORPRECIO, Huzaifa RANGWALA
  • SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN INCLUDING INTERMEDIATES CONTAINING -SO2-(P-TOLYL) GROUPS
    Publication number: 20160137661
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Application
    Filed: May 30, 2014
    Publication date: May 19, 2016
    Inventors: Fabio E.S. SOUZA, Alena RUDOLPH, Dino ALBERICO, Robert JORDAN, Ming PAN, Boris GORIN
  • Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
    Patent number: 9278979
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: March 8, 2016
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
    Patent number: 9062020
    Abstract: Disclosed is a compound of formula 1, as shown below, where R1, R2, R3, R4, R5, R6 and R7 are as described herein. Also, disclosed is a process for the preparation of compounds of formula 1, and intermediates used therein. The compound of formula 1 can be useful for preparation of halichondrin analogs such as Eribulin.
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: June 23, 2015
    Assignee: ALPHORA RESEARCH INC.
    Inventors: Fabio E. S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Dino Alberico
  • SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN
    Publication number: 20150065733
    Abstract: Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7?, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 5, 2015
    Inventors: Fabio E.S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Teng Ko Ngooi, Jason A. Bexrud, Ricardo Orprecio, Huzaifa Rangwala
  • 2-((2S,3S,4R,5R)-5-((S)-3-AMINO-2-HYDROXYPROP-1-YL)-4-METHOXY-3-(PHENYLSULFONYLMETHYL)TETRAHYDROFURAN-2-YL)ACETALDEHYDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20150011776
    Abstract: Disclosed is a compound of formula 1, as shown below, where R1, R2, R3, R4, R5, R6 and R7 are as described herein. Also, disclosed is a process for the preparation of compounds of formula 1, and intermediates used therein. The compound of formula 1 can be useful for preparation of halichondrin analogs such as Eribulin.
    Type: Application
    Filed: December 24, 2012
    Publication date: January 8, 2015
    Inventors: Fabio E.S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Dino Alberico
  • Transition metal mediated process
    Publication number: 20030109714
    Abstract: This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.
    Type: Application
    Filed: September 20, 2002
    Publication date: June 12, 2003
    Inventors: Neil Wishart, Alena Rudolph, Kurt Ritter