Abstract: The present invention relates to a microfluidic device for introducing pores into and/or enhancing the diameter of pores in the cell membrane of a cell by cell deformation for delivery of cargo molecules into said cell, the device comprising: an inlet and an outlet; and at least one microfluidic channel positioned between said inlet and said outlet, defining a lumen, adapted to allow a cell and cargo molecules in a suspension solution to pass therethrough; wherein the at least one microfluidic channel comprises at least two constrictions with different cross-sections, wherein one of said constrictions has a cross-section that is larger than the average cross-section of said cell and adapted to apply hydrodynamic forces to said cell and a second of said constrictions has a cross-section that is equal to or smaller than the average cross-section of said cell and adapted to apply contact-based compression forces to said cell, while allowing said cell to pass through said constrictions.

Abstract: The present invention relates to peptides and peptidomimetics as well as their medical use in the treatment of hyperproliferative diseases and inflammatory diseases.