Patents by Inventor Alenka Jeriha

Alenka Jeriha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of amlodipine benzenesulphonate
    Patent number: 5438145
    Abstract: There is disclosed a process for the preparation of 3-ethyl 5-methyl (.+-.) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyri dine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula ##STR1## wherein 3-ethyl 5-methyl (.+-.) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl -3,5-pyridinecarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20.degree. C. to the reflux temperature and the title compound is isolated and purified.Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: August 1, 1995
    Assignee: LEK, tovarna farmecevtskih in kemicnih izdelkov
    Inventors: Borut Furlan, Anton Copar, Alenka Jeriha
  • 3-ethyl 5-methyl(.+-.)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-d ihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
    Patent number: 5389654
    Abstract: There is disclosed a process for the preparation of 3-ethyl 5-methyl (.+-.) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyri dine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula ##STR1## wherein 3-ethyl 5-methyl (.+-.) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl -3,5-pyridinedicarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20.degree. C. to the reflux temperature and the title compound is isolated and purified.Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: February 14, 1995
    Assignee: LEK, tovarna, farmacevtskih in Kemicnih . . .
    Inventors: Borut Furlan, Anton Copar, Alenka Jeriha