Patents by Inventor Alessandra Cesano

Alessandra Cesano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating malignancies
    Patent number: 6022538
    Abstract: A method of treating tumors which involves a synergistic combination of chemotherapy and cell therapy is provided. The method of the invention permits reduced amounts of chemotherapeutic agents to be administered, resulting in a reduction of the side effects often associated therewith.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: February 8, 2000
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Daniela Santoli, Giovanni Rovera, Alessandra Cesano
  • Modified TALL-104 cells to treat cancer
    Patent number: 5820856
    Abstract: This invention provides a method of using modified human cytotoxic TALL-104 cell line, which is characterized by activity against tumor cells. More particularly, the method comprises treating bone marrow cells of an immunosuppressed mammalian patient with the modified TALL-104 cell line and reinjecting the treated bone marrow into the patient, as a treatment of hematological malignancies. Also provided are effective and safe methods of use of the modified cells in the manufacture of a veterinary composition for adoptive therapy of canine lymphoma and feline leukemias.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: October 13, 1998
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Daniela Santoli, Giovanni Rovera, Alessandra Cesano
  • Modified cytotoxic tall cell line and compositions and methods for manufacture and use thereof as therapeutic reagents for cancer
    Patent number: 5702702
    Abstract: The invention provides a modified human cytotoxic T cell line, which is characterized by dual activity in vitro and in vivo against malignant cells and virus-infected cells. Also provided are effective and safe methods for use of the modified cells in adoptive therapy of cancer and untreatable vital diseases in MHC-mismatched recipients, and in marrow purging to achieve complete eradication of residual tumor cells from marrows of patients with leukemia and other types of cancer. Also provided are effective and safe methods for use of the cytokine stimulated, irradiated TALL-104 cells in the manufacture of a veterinary composition for adoptive therapy of canine and feline malignancies.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 30, 1997
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Daniela Santoli, Giovanni Rovera, Alessandra Cesano
  • Modified cytotoxic tall cell line and compositions and methods for manufacture and use thereof as therapeutic reagents for cancer
    Patent number: 5683690
    Abstract: The invention provides a modified human cytotoxic T cell line TALL-104, which is characterized by dual activity in vitro and in vivo against tumor cells and virus-infected cells. Also provided are effective and safe methods for use of the modified TALL-104 cells in adoptive therapy of cancer and untreatable viral diseases in MHC-mismatched recipients, and in marrow purging to achieve complete eradication of residual tumor cells from marrows of patients with leukemia and other types of cancer. Also provided are effective and safe methods for use of the modified TALL-104 cells in the manufacture of a veterinary composition for adoptive therapy of canine lymphoma and feline leukemias.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: November 4, 1997
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Daniela Santoli, Giovanni Rovera, Alessandra Cesano
  • Cytotoxic T-ALL cell lines and uses therefor
    Patent number: 5272082
    Abstract: The invention provides cytotoxic T-ALL cell lines, and modified cytotoxic T-ALL cell lines which contain a heterologous DNA sequence. The DNA sequence may encode a product capable of stabilizing or potentiating the tumoricidal activity of the cytotoxic cell lines and a product capable of controlling the growth of the cell line. Methods for use of these cell lines are also provided.
    Type: Grant
    Filed: March 30, 1992
    Date of Patent: December 21, 1993
    Assignee: The Wistar Institute of Anatomy & Biology
    Inventors: Daniela Santoli, Giovanni Rovera, Alessandra Cesano