Abstract: Medical device systems and methods are disclosed herein for assessing motor symptoms in Parkinson's disease patients through passively and/or actively acquired sensor data of motor behaviors and generating motor system assessments. Passive movement data and/or active motor performance data collected from Parkinson's disease patients is representative of EQ-5D-5L, PDQ-39, and/or MDS-UPDRS health status measurement data to more accurately predict quality of life, health status, and disease severity of Parkinson's disease patients. The generated motor system assessment may be used to provide neurologists and other health professionals with more accurate treatment recommendations and disease management protocols rather than using patient surveys alone.