Patents by Inventor Alessandra Villa

Alessandra Villa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to tumour antigens
    Patent number: 11629199
    Abstract: The present application relates to specific binding members that bind carbonic anhydrase IX (CAIX). In particular, the present application relates to the treatment, diagnosis and detection of tumours, e.g. solid tumours, using specific binding members that bind CAIX. The specific binding member may be conjugated to a biocidal or cytotoxic molecule, or to a detectable label.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 18, 2023
    Inventors: Laura Gualandi, Sarah Wulhfard, Francesca Pretto, Catherine Pemberton-Ross, Alessandra Villa, Roberto De Luca
  • Antibodies To Tumour Antigens
    Publication number: 20210054095
    Abstract: The present application relates to specific binding members that bind carbonic anhydrase IX (CAIX). In particular, the present application relates to the treatment, diagnosis and detection of tumours, e.g. solid tumours, using specific binding members that bind CAIX. The specific binding member may be conjugated to a biocidal or cytotoxic molecule, or to a detectable label.
    Type: Application
    Filed: December 18, 2018
    Publication date: February 25, 2021
    Inventors: Laura Gaulandi, Sarah Wuihfard, Francesca Pretto, Catherine Pemberton-Ross, Alessandra Villa, Roberto De Luca
  • EDB Targeting IL-12 Compositions
    Publication number: 20200397915
    Abstract: The present invention relates to compositions comprising an IL-12 protein having a first and second subunit, an EDB-binding domain, and a linker between the IL-12 protein and the EDB-binding domain.
    Type: Application
    Filed: February 8, 2019
    Publication date: December 24, 2020
    Inventors: Mattia Matasci, Tiziano Ongaro, Alessandra Villa
  • Antibodies for treatment and diagnosis of inflammatory bowel disease
    Patent number: 10647760
    Abstract: The invention relates to the diagnosis and treatment of diseases, including inflammatory disorders, proliferative disorders and autoimmune diseases. The invention provides, and involves the use of, antibody molecules that bind: i) lysozyme, ii) neutrophil elastase, iii) tissue inhibitor of metalloproteinase-1 (TIMP-1), or iv) the D domain of Tenascin-C. The invention also relates to the use of antibody molecules that bind v) the IIICS isoform of fibronectin, vi) the Extra Domain-B (ED-B) of fibronectin, vii) matrix-metalloproteinase 3 (MMP3), or viii) the A1 domain of tenascin-C in the diagnosis and treatment of inflammatory disorders such as inflammatory bowel disease.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: May 12, 2020
    Assignee: PHILOGEN S.P.A.
    Inventors: Sarah Wulhfard, Alessandra Villa, Catherine Pemberton Ross, Francesca Pretto, Filippa Fleetwood
  • IMMUNOCYTOKINES WITH PROGRESSIVE ACTIVATION MECHANISM
    Publication number: 20190351024
    Abstract: The present invention relates to a combination comprising at least an immunocytokine comprising at least a primary binding protein or peptide and a cytokine, fused or conjugated to one another, and a secondary binding molecule capable of binding to at least a section of at least one cytokine comprised in the immunocytokine.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 21, 2019
    Inventors: Giovanni Neri, Alessandra Villa, Florent Samain, Martina Bigatti
  • INTESTINAL ANTIGENS FOR PHARMACODELIVERY APPLICATIONS
    Publication number: 20190309060
    Abstract: The present invention relates to the treatment of intestinal diseases and disorders, such as inflammatory bowel disease (IBD). The invention involves antibodies and the use of antibodies which bind antigens that have been shown to be over-expressed in the intestine compared to other organs, including antigens cadherin-17, anterior gradient protein 2 homolog, galectin-4, and galectin-2. The antibodies may be conjugated to anti-inflammatory or immunosuppressive agents, as required.
    Type: Application
    Filed: January 13, 2017
    Publication date: October 10, 2019
    Inventors: Alessandra VILLA, Catherine PEMBERTON ROSS, Francesca PRETTO, Filippa FLEETWOOD, Tim FUGMANN
  • ANTIBODIES FOR TREATMENT AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE
    Publication number: 20190062414
    Abstract: The invention relates to the diagnosis and treatment of diseases,including inflammatory disorders, proliferative disorders and autoimmune diseases. The invention provides, and involves the use of, antibody molecules that bind: i) lysozyme, ii) neutrophil elastase, iii) tissue inhibitor of metalloproteinase-1 (TIMP-1), or iv) the D domain of Tenascin-C. The invention also relates to the use of antibody molecules that bind v) the IIICS isoform of fibronectin, vi) the Extra Domain-B (ED-B) of fibronectin, vii) matrix-metalloproteinase 3 (MMP3), or viii) the A1 domain of tenascin-C in the diagnosis and treatment of inflammatory disorders such as inflammatory bowel disease.
    Type: Application
    Filed: December 9, 2016
    Publication date: February 28, 2019
    Inventors: Sarah Wulhfard, Alessandra Villa, Catherine Pemberton Ross, Francesca Pretto, Filippa Fleetwood
  • Antigen associated with lung cancers and lymphomas
    Patent number: 10202442
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of lung cancer and lymphoma.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: February 12, 2019
    Assignee: Philogen S.P.A.
    Inventors: Dario Neri, Alessandra Villa, Eveline Trachsel, Jascha-Nikolai Rybak
  • Antigen associated with the neovasculature of tumour metastases
    Patent number: 9896503
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: February 20, 2018
    Assignee: Philogen S.P.A.
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • ANTIGEN ASSOCIATED WITH LUNG CANCERS AND LYMPHOMAS
    Publication number: 20160376356
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of lung cancer and lymphoma.
    Type: Application
    Filed: September 9, 2016
    Publication date: December 29, 2016
    Applicant: Philogen S.P.A.
    Inventors: Dario Neri, Alessandra Villa, Eveline Trachsel, Jascha-Nikolai Rybak
  • NOVEL ANTIGEN ASSOCIATED WITH THE NEOVASCULATURE OF TUMOUR METASTASES
    Publication number: 20160083461
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.
    Type: Application
    Filed: October 5, 2015
    Publication date: March 24, 2016
    Applicant: PHILOGEN S.P.A.
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • Antigen associated with the neovasculature of tumour metastases
    Patent number: 9181347
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumor metastases.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 10, 2015
    Assignee: Philogen S.p.A.
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • ANTIGEN ASSOCIATED WITH LUNG CANCERS AND LYMPHOMAS
    Publication number: 20150030536
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of lung cancer and lymphoma.
    Type: Application
    Filed: August 11, 2014
    Publication date: January 29, 2015
    Inventors: Dario Neri, Alessandra Villa, Eveline Trachsel, Jascha-Nikolai Rybak
  • Display library for antibody selection
    Patent number: 8735331
    Abstract: Synthetic antibody display library containing human germline antibody molecules with variation in VH CDR3 and VL CDR3 and at position 52 of VH CDR2, for screening and selection of antibody molecules specific for antigens of interest.
    Type: Grant
    Filed: September 7, 2009
    Date of Patent: May 27, 2014
    Assignee: Philochem AG
    Inventor: Alessandra Villa
  • NOVEL ANTIGEN ASSOCIATED WITH THE NEOVASCULATURE OF TUMOUR METASTASES
    Publication number: 20130280759
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.
    Type: Application
    Filed: July 3, 2013
    Publication date: October 24, 2013
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • NOVEL ANTIGEN ASSOCIATED WITH THE NEOVASCULATURE OF TUMOUR METASTASES
    Publication number: 20130266511
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.
    Type: Application
    Filed: June 6, 2013
    Publication date: October 10, 2013
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • Antigen associated with the neovasculature of tumour metastases
    Patent number: 8481684
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 9, 2013
    Assignee: Philogen S.p.A.
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • NOVEL ANTIGEN ASSOCIATED WITH THE NEOVASCULATURE OF TUMOUR METASTASES
    Publication number: 20130040361
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases.
    Type: Application
    Filed: August 9, 2012
    Publication date: February 14, 2013
    Inventors: Jascha-Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • Antigen associated with the neovasculature of tumour metastases
    Patent number: 8263041
    Abstract: The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumor metastases.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: September 11, 2012
    Assignee: Philogen, S.p.A.
    Inventors: Jascha Nikolai Rybak, Christoph Rosli, Alessandra Villa, Giovanni Neri, Dario Neri
  • Display Library for Antibody Selection
    Publication number: 20110236372
    Abstract: Synthetic antibody display library containing human germline antibody molecules with variation in VH CDR3 and VL CDR3 and at position 52 of VH CDR2, for screening and selection of antibody molecules specific for antigens of interest.
    Type: Application
    Filed: September 7, 2009
    Publication date: September 29, 2011
    Inventor: Alessandra Villa