Patents by Inventor Alessandro Ascione

Alessandro Ascione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody derivatives
    Patent number: 8822648
    Abstract: An anti-CEA scFv having an uncleaved Pel B leader sequence is surprisingly stable and is highly specific for CEA and CEACAM1.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 2, 2014
    Assignees: Instituto Superiore di Sanita, Diatheva s.r.l.
    Inventors: Maurizio Cianfriglia, Michela Flego, Alessandro Ascione, Valentina Fiori, Sabrina Domicini, Alessandra Mallano, Diego Moricoli, Silvia Zamboni
  • Single-chain variable fragment (scFv) able to recognize and bind CD99 human protein
    Patent number: 8710194
    Abstract: The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. The single-chain variable fragment is able to recognize and specifically and selectively bind the epitope of the extracellular domain of CD99 human protein expressed on Ewing sarcoma cells. The fragment can thus be used for the diagnosis and 10 treatment of Ewing sarcoma.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: April 29, 2014
    Assignee: Istituto Ortopedico Rizzoli
    Inventors: Piero Picci, Katia Scotlandi, Alessandro Ascione, Maurizio Cianfriglia, Maria Luisa Dupuis, Michela Flego, Mara Gellini, Alessandra Mallano
  • SINGLE-CHAIN VARIABLE FRAGMENT (SCFV) ABLE TO RECOGNIZE AND BIND CD99 HUMAN PROTEIN
    Publication number: 20120282257
    Abstract: The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. The single-chain variable fragment is able to recognize and specifically and selectively bind said epitope expressed on Ewing sarcoma cells. The fragment can thus be used for the diagnosis and treatment of Ewing sarcoma.
    Type: Application
    Filed: November 12, 2010
    Publication date: November 8, 2012
    Inventors: Piero Picci, Katia Scotlandi, Alessandro Ascione, Maurizio Cianfriglia, Maria Luisa Dupuis, Michela Flego, Mara Gellini, Alessandra Mallano