Patents by Inventor Alessandro Giuseppe ELIA

Alessandro Giuseppe ELIA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING AN AMORPHOUSE SOLID DISPERSION AND PHARMACEUTICAL COMPOSITION FOR STABILIZING ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20230398222
    Abstract: The present invention relates to a method for producing an amorphous solid dispersion of at least one active pharmaceutical ingredient in a polymer matrix. The Invention further relates to a pharmaceutical composition using polymers as an excipient and particularly to an improved pharmaceutical composition comprising polyvinyl alcohol grades with different degrees of hydrolysis, which is suitable to stabilize active pharmaceutical ingredients.
    Type: Application
    Filed: October 20, 2021
    Publication date: December 14, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas KIPPING, Finn BAUER, Nicole DI GALLO, Anja-Nadine KNUETTEL, Alessandro Giuseppe ELIA
  • PHARMACEUTICAL COMPOSITION AND METHOD FOR ENHANCING SOLUBILITY OF POORLY SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20230390204
    Abstract: The present invention relates to pharmaceutical compositions using polymers as an excipient. Particularly, the invention relates to a pharmaceutical composition comprising polyvinyl alcohol which is suitable to enhance solubility of poorly soluble active pharmaceutical ingredients in aqueous media. The present invention also relates to a method for enhancing solubility of poorly soluble active pharmaceutical ingredients.
    Type: Application
    Filed: October 27, 2021
    Publication date: December 7, 2023
    Applicant: Merck Patent GmbH
    Inventors: Thomas KIPPING, Finn BAUER, Nicole DI GALLO, Anja-Nadine KNUETTEL, Alessandro Giuseppe ELIA
  • Hot melt extrusion composition using direct compressible excipient as plasticizer
    Patent number: 11510986
    Abstract: The present invention relates to the use of spray-dried sorbitol, such as Parteck® SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: November 29, 2022
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Lubda, Mengyao Zheng, Alessandro Giuseppe Elia, Nicole Di Gallo
  • HOT MELT EXTRUSION COMPOSITION USING DIRECT COMPRESSIBLE EXCIPIENT AS PLASTICIZER
    Publication number: 20200254098
    Abstract: The present invention relates to the use of spray-dried sorbitol, such as Parteck® SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.
    Type: Application
    Filed: May 10, 2017
    Publication date: August 13, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter LUBDA, Mengyao ZHENG, Alessandro Giuseppe ELIA, Nicole DI GALLO