Patents by Inventor Alessandro GRILLO

Alessandro GRILLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER
    Publication number: 20240239799
    Abstract: The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6?H-spiro[piperidine-4,5?-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.
    Type: Application
    Filed: April 1, 2022
    Publication date: July 18, 2024
    Applicants: C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING, IRBM S.p.A.
    Inventors: Romano DI FABIO, Christian MONTALBETTI, Alessia PETROCCHI, Alessandro GRILLO, Pietro RANDAZZO, Ilaria ROSSETTI, Alina CIAMMAICHELLA
  • AZABICYCLIC SHP2 INHIBITORS
    Publication number: 20240109900
    Abstract: The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I).
    Type: Application
    Filed: February 8, 2022
    Publication date: April 4, 2024
    Inventors: Alina CIAMMAICHELLA, Romano DI FABIO, Federica FERRIGNO, Paola FEZZARDI, Christian MONTALBETTI, Alessia PETROCCHI, Nicola RELITTI, Ilaria ROSSETTI, Alessio SFERRAZZA, Esther TORRENTE, Luca FERRANTE, Alessandro GRILLO
  • INHIBITORS OF HEPATITIS B VIRUS
    Publication number: 20230076319
    Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.
    Type: Application
    Filed: October 4, 2022
    Publication date: March 9, 2023
    Inventors: Raffaele DE FRANCESCO, Lorena DONNICI, Luca GUIDOTTI, Matteo IANNACONE, Romano DI FABIO, Vincenzo SUMMA, Adolfo PRANDI, Pietro RANDAZZO, Davide GORNATI, Alessandro GRILLO, Luca FERRANTE, Leda Ivanova BENCHEVA, Marilenia DE MATTEO, Marco FERRARA
  • Tricyclic inhibitors of Hepatitis B virus
    Patent number: 11504382
    Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: November 22, 2022
    Assignee: Antios Therapeutics, Inc.
    Inventors: Raffaele De Francesco, Lorena Donnici, Luca Guidotti, Matteo Iannacone, Romano Di Fabio, Vincenzo Summa, Adolfo Prandi, Pietro Randazzo, Davide Gornati, Alessandro Grillo, Luca Ferrante, Leda Ivanova Bencheva, Marilenia De Matteo, Marco Ferrara
  • OXALAMIDO-SUBSTITUTED TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS
    Publication number: 20220241241
    Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.
    Type: Application
    Filed: May 25, 2020
    Publication date: August 4, 2022
    Applicants: ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM, OSPEDALE SAN RAFFAELE S.R.L., IRBM S.P.A.
    Inventors: Raffaele DE FRANCESCO, Lorena DONNICI, Luca GUIDOTTI, Matteo IANNACONE, Romano DI FABIO, Vincenzo SUMMA, Adolfo PRANDI, Pietro RANDAZZO, Leda IVANOVA BENCHEVA, Marilenia DE MATTEO, Luca FERRANTE, Davide GORNATI, Alessandro GRILLO
  • TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS
    Publication number: 20220110943
    Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.
    Type: Application
    Filed: August 9, 2019
    Publication date: April 14, 2022
    Applicants: OSPEDALE SAN RAFFAELE S.R.L., IRBM S.P.A., PROMIDIS S.R.L., ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM
    Inventors: Raffaele DE FRANCESCO, Lorena DONNICI, Luca GUIDOTTI, Matteo IANNACONE, Romano DI FABIO, Vincenzo SUMMA, Adolfo PRANDI, Pietro RANDAZZO, Davide GORNATI, Alessandro GRILLO, Luca FERRANTE, Leda Ivanova BENCHEVA, Marilenia DE MATTEO, Marco FERRARA