Patents by Inventor Alessandro Maiocchi

Alessandro Maiocchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220370646
    Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.
    Type: Application
    Filed: October 20, 2020
    Publication date: November 24, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Zsolt BARANYAI, Mariangela BOCCALON, Federica BUONSANTI, Federico CRIVELLIN, Alessandro MAIOCCHI, Roberta MAZZON, Fabio TEDOLDI, Fulvio UGGERI
  • Publication number: 20220348923
    Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.
    Type: Application
    Filed: September 16, 2020
    Publication date: November 3, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Vittorio DE FRANCISCIS, Carla Lucia ESPOSITO, Silvia CATUOGNO, Silvia NUZZO, Alessandro MAIOCCHI, Margherita IABONI, Aldo DI VITO, Erika REITANO, Luisa POGGI
  • Patent number: 11274308
    Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 15, 2022
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Vittorio De Franciscis, Silvia Catuogno, Carla Lucia Esposito, Alessandro Maiocchi, Margherita Iaboni, Luisa Poggi, Erika Reitano
  • Publication number: 20220062444
    Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).
    Type: Application
    Filed: December 17, 2019
    Publication date: March 3, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio AIME, Giuseppe FERRAUTO, Eliana GIANOLIO, Luciano LATTUADA, Alessandro MAIOCCHI
  • Publication number: 20220054663
    Abstract: The present invention relates to a labeling procedure for the incorporation, in mild reaction conditions, of sensitive and thermosensitive targeting molecules into a [99mTc(N)(PNP)]-based compound suitable for a kit formulation.
    Type: Application
    Filed: September 2, 2021
    Publication date: February 24, 2022
    Applicant: BRACCO IMAGING SPA
    Inventors: Cristina BOLZATI, Nicola SALVARESE, Fiorenzo REFOSCO, Simona GHIANI, Alessandro MAIOCCHI, Barbara SPOLAORE
  • Publication number: 20220016275
    Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 20, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Zsolt BARANYAI, Simona GHIANI, Alessandro MAIOCCHI, Ivan HAWALA
  • Publication number: 20210395832
    Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.
    Type: Application
    Filed: November 8, 2019
    Publication date: December 23, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Andrea FERRARIS, Erika REITANO, Alessandro MAIOCCHI
  • Patent number: 11160886
    Abstract: The present invention relates to a labeling procedure for the incorporation, in mild reaction conditions, of sensitive and thermosensitive targeting molecules into a [99m Tc(N)(PNP)]-based compound suitable for a kit formulation.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 2, 2021
    Assignee: BRACCO IMAGING SPA
    Inventors: Cristina Bolzati, Nicola Salvarese, Fiorenzo Refosco, Simona Ghiani, Alessandro Maiocchi, Barbara Spolaore
  • Publication number: 20210292762
    Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.
    Type: Application
    Filed: July 24, 2019
    Publication date: September 23, 2021
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Vittorio DE FRANCISCIS, Silvia CATUOGNO, Carla Lucia ESPOSITO, Alessandro MAIOCCHI, Margherita IABONI, Luisa POGGI, Erika REITANO
  • Patent number: 10780184
    Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 22, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Simona Ghiani, Alessandro Maiocchi, Lara Caminiti, Luigi Miragoli
  • Patent number: 10682427
    Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: June 16, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Alessandro Maiocchi, Chiara Brioschi, Fulvio Uggeri, Giovanni Valbusa
  • Publication number: 20200078479
    Abstract: The present invention relates to a labeling procedure for the incorporation, in mild reaction conditions, of sensitive and thermosensitive targeting molecules into a [99m Tc(N)(PNP)]-based compound suitable for a kit formulation.
    Type: Application
    Filed: December 15, 2017
    Publication date: March 12, 2020
    Applicant: BRACCO IMAGING SPA
    Inventors: Cristina BOLZATI, Nicola SALVARESE, Fiorenzo REFOSCO, Simona GHIANI, Alessandro MAIOCCHI, Barbara SPOLAORE
  • Publication number: 20190167818
    Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty add; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindele derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
    Type: Application
    Filed: January 31, 2019
    Publication date: June 6, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Simona GHIANI, Alessandro MAIOCCHI, Lara CAMINITI, Luigi MIRAGOLI
  • Patent number: 10265422
    Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: April 23, 2019
    Assignee: Bracco Imaging S.P.A.
    Inventors: Zsolt Baranyai, Zoltán Garda, Simona Ghiani, Ferenc Krisztián Kálmán, László Krusper, Alessandro Maiocchi, Gyula Tircsó, Imre Toth
  • Patent number: 10251960
    Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 9, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Simona Ghiani, Alessandro Maiocchi, Lara Caminiti, Luigi Miragoli
  • Patent number: 10039843
    Abstract: The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 7, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Chiara Brioschi, Claudia Cabella, Simona Ghiani, Alessandro Maiocchi, Luigi Miragoli, Massimo Visigalli
  • Patent number: 9952300
    Abstract: The present invention generally relates to paramagnetic contrast agents and a Dynamic Contrast Enhanced-MRI method for the non-invasive estimation of the delivery of a macromolecular anticancer drug or pro-drug within pathological tissues and, especially, in solid tumors and for the optimization of anticancer therapies.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: April 24, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Raffaella Giavazzi, Alessandro Maiocchi, Michele Moschetta, Giovanni Valbusa
  • Publication number: 20180036436
    Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: February 25, 2016
    Publication date: February 8, 2018
    Applicant: Bracco Imaging S.p.A.
    Inventors: Zsolt BARANYAI, Zoltán GARDA, Simona GHIANI, Ferenc Krisztián KÁLMÁN, László KRUSPER, Alessandro MAIOCCHI, Gyula TIRCSÓ, Imre TOTH
  • Publication number: 20170340755
    Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.
    Type: Application
    Filed: December 18, 2015
    Publication date: November 30, 2017
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Alessandro MAIOCCHI, Chiara BRIOSCHI, Fulvio UGGERI, Giovanni VALBUSA
  • Publication number: 20170252464
    Abstract: A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.
    Type: Application
    Filed: July 22, 2015
    Publication date: September 7, 2017
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Elena ELISEI, Attilio CESARO, Marta FILIBIAN, Pietro CARRETTA, Sonia COLOMBO SERRA, Alessandro MAIOCCHI, Fabio TEDOLDI