Patents by Inventor Alessandro Negro

Alessandro Negro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of hyaluronic acid in or
    Patent number: 10017802
    Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: July 10, 2018
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Susanna Vaccaro, Luciano Messina
  • Process for the production of hyaluronic acid in or bacillus megaterium
    Patent number: 9695453
    Abstract: A method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 4, 2017
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Sonia Bisicchia
  • PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS SUBTILIS
    Publication number: 20160237465
    Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.
    Type: Application
    Filed: February 17, 2016
    Publication date: August 18, 2016
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza CORSA, Alessandro NEGRO, Susanna VACCARO, Luciano MESSINA
  • Method for obtaining recombinant host bacterial cells that produce hyaluronic acid
    Patent number: 9290785
    Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: March 22, 2016
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Susanna Vaccaro, Luciano Messina
  • PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS MEGATERIUM
    Publication number: 20160032337
    Abstract: A method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.
    Type: Application
    Filed: October 15, 2015
    Publication date: February 4, 2016
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza CORSA, Alessandro NEGRO, Sonia BISICCHIA
  • Process for the production of hyaluronic acid in or
    Patent number: 9163270
    Abstract: A method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: October 20, 2015
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Sonia Bisicchia
  • PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS MEGATERIUM
    Publication number: 20140099673
    Abstract: The present invention relates to a method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid.
    Type: Application
    Filed: September 9, 2011
    Publication date: April 10, 2014
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Sonia Bisicchia
  • PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS SUBTILIS
    Publication number: 20130189740
    Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.
    Type: Application
    Filed: September 9, 2011
    Publication date: July 25, 2013
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Susanna Vaccaro, Luciano Messina
  • Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda infected with recombinant baculovirus
    Patent number: 5641649
    Abstract: The present invention is directed towards a method of producing a DNA sequence encoding human osteogenic protein, OP-1, using recombinant DNA techniques. The DNA sequence encoding OP-1 is utilized in the preparation of recombinant baculovirus, which is then used to infect cells from Spodoptera frugiperda. The present invention is further drawn to the production of physiologically active OP-1 protein by culturing the infected insect cells and to recombinant baculovirus containing DNA encoding human OP-1 as well as insect cells infected with the recombinant baculovirus. The recombinant OP-1 produced by the present invention may be used to produce pharmaceutical compositions useful in the treatment of bone diseases, orthopedic diseases, bone defects, and trauma.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: June 24, 1997
    Assignee: Italian Ministry for Universities and Scientific and Technological Research
    Inventors: Ombretta Stanchi, Alessandro Negro, Lanfranco Callegaro
  • Vectors for expression of NGF in eukaryotic cells
    Patent number: 5457034
    Abstract: This invention relates to a process for obtaining, from transformed cells, the polypeptide called nerve growth factor (.beta.-NGF), and more precisely to the process for obtaining, by recombinant DNA technology using genetic constructions insertible in appropriate eukaryotic cell lines, the biologically active human mature form (.beta.-subunit).
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: October 10, 1995
    Assignee: Fidia, S.p.A.
    Inventors: Francesco della Valle, Lanfranco Callegaro, Alessandro Negro