Abstract: A machine and a process for bending filiform thermoplastic material, such as a tube, by using a machine for bending tubes provided with a heating apparatus governed by a programmable control unit with a core body positionable inside the portion of the tube to be bent, suitable for being heated in a sector-by-sector basis, said sectors being independent of each other and heatable independently of each other.

Abstract: The invention relates to a keyboard (10) for writing musical scores, suitable for blind users, characterized by—an input module (12) connectible to a remote computer and provided with a plurality of keys divided into sets of keys, of which a first set of keys (30) is configured to generate signals representative of the pitch of the musical notes by a musical staff wherein the improvement comprises lines in relief that ensure tactile feedback and a second set of keys (40) is configured to generate signals representative of the duration of the musical notes;—a control unit (150) configured to translate sequences of pressed keys into corresponding signals to be sent to a remote computer, said signals being interpretable in terms of musical notation elements which can be represented on a computer.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: The invention relates to a keyboard (10) for writing musical scores, suitable for blind users, characterized by—an input module (12) connectible to a remote computer and provided with a plurality of keys divided into sets of keys, of which a first set of keys (30) is configured to generate signals representative of the pitch of the musical notes by a musical staff wherein the improvement comprises lines in relief that ensure tactile feedback and a second set of keys (40) is configured to generate signals representative of the duration of the musical notes;—a control unit (150) configured to translate sequences of pressed keys into corresponding signals to be sent to a remote computer, said signals being interpretable in terms of musical notation elements which can be represented on a computer.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Abstract: The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nano particles in medicine.

Abstract: A machine to bend pipes that includes: a plate that is configured and arranged to move along an X-axis; a bending head connected to the plate, where the bending head is capable of moving along a Z-axis and is equipped with at least one bending arm and at least one bending die; and at least one calendering jig, which is located at a position that is before the bending die, with respect to a feeding direction of the pipe. The calendering jig includes at least two first rolls used to lock the pipe and at least one second roll that is configured and arranged for determining the calendering radius of the pipe, wherein the at least one second roll is anchored to the plate. The bending head is configured and arranged to move in the Z direction with respect to both the plate and the second roll.

Abstract: Equipment for taking a bent pipe provided with a mechanical arm, preferably featuring three degrees of freedom, operated by first means controlled by at least one preferably programmable first electronic device, and equipped with at least one container located at an end of the arm, means facilitating the unloading of the bent pipe into the container, and means to close it and to unload the bent pipe

Abstract: A machine to bend pipes and the like, equipped with at least one bending die working table more than the machines used to bend pipes and the like,

Abstract: The invention belongs in the field of machines for bending tubes and refers in particular to a machine (1) comprising a supporting base (2), a positioning device (3) for the tube (7) to be bent and a bending device (4) for said tube (7) characterised by having devices capable of rotating through up to 360° in order to bend said tube (7) in various bending planes, including starting alternatively from either end of said tube or, as necessary, at an intermediate part.