Abstract: The present patent disclosure describes a new method and a new device for determining a spatial distribution of at least one tissue parameter within a sample based on a time domain magnetic resonance, TDMR, signal emitted from the sample after excitation of the sample according to an applied pulse sequence. The spatial distribution is determined using a calculated sparse Hessian, wherein the sparse Hessian is calculated based on the applied pulse sequence.

Abstract: The present patent disclosure relates to a method and a device 700 for determining a spatial distribution of at least one tissue parameter within a sample on a time domain magnetic resonance, TDMR, signal emitted from the sample after excitation of the sample according to an applied pulse sequence, a method of obtaining at least one time dependent parameter relating to a magnetic resonance, MR, signal emitted from a sample after excitation of the sample according to an applied spin echo pulse sequence, and a computer program product for performing the methods. A TDMR signal model is used to approximate the emitted time domain magnetic resonance signal. The model is factorized into one or more first matrix operators that have a non-linear dependence on the at least one tissue parameter and a remainder of the TDMR signal model.

Abstract: The present patent disclosure describes a new method and a new device for determining a spatial distribution of at N least one tissue parameter within a sample based on a time domain magnetic resonance, TDMR, signal emitted from the sample after excitation of the sample according to an applied pulse sequence. The spatial distribution is determined using a calculated sparse Hessian, wherein the sparse Hessian is calculated based on the applied pulse sequence.

Abstract: A system for performing time-domain magnetic resonance imaging includes an excitation device for transiently exciting a sample thereby causing the sample to emit an MRI signal. A receiving coil receives the MRI signal. A simulated signal of the receiving coil is generated in a time domain, based on a plurality of spatial parameter distributions, wherein the spatial parameter distributions include a spatial distribution of a magnetization, wherein the spatial parameter distributions further include at least one of a spatial distribution of a material property of a material of the sample and a spatial distribution of an electromagnetic field. An objective function is based on a difference between the received MRI signal and the simulated signal in the time domain. The plurality of spatial parameter distributions are fitted based on the objective function. The sample is excited again before the sample reaches an equilibrium state.

Abstract: A system for performing time-domain magnetic resonance imaging comprises an excitation device for transiently exciting a sample thereby causing the sample to emit an MRI signal. A receiving coil receives the MRI signal. A simulated signal of the receiving coil is generated in a time domain, based on a plurality of spatial parameter distributions, wherein the spatial parameter distributions include a spatial distribution of a magnetization, wherein the spatial parameter distributions further include at least one of a spatial distribution of a material property of a material of the sample and a spatial distribution of an electromagnetic field. An objective function is based on a difference between the received MRI signal and the simulated signal in the time domain. The plurality of spatial parameter distributions are fitted based on the objective function. The sample is excited again before the sample reaches an equilibrium state.