Abstract: Immune-restricted peptides, especially HLA-A2 restricted peptides. Specifically, immune-restricted peptides according to the formula: wherein: P1 is selected from the group consisting of am-phg, PHG, 3-PYRA, 3-THI, SOME, CSCF3 and CSME; P2, P3, P4, PC-2, PC-1, and PC are each independently a naturally, or non-naturally, occurring amino acid, wherein P2 and P3 each comprise a hydrophobic linear or branched substitution, wherein P2 can further be a fluorinated substitution, P4 comprises a methylated alpha nitrogen atom; PC-2 comprises a fluorinated aromatic substitution; PC comprises unsaturated or saturated side chains and/or carboxyl isosteres, or a saturated linear carbon chain containing 2 to 4 carbon atoms with or without an oxygen or sulphur atom within the chain and/or a carboxyl isostere; Pm is a naturally occurring amino acid; and n is an integer of 1-9.