Patents by Inventor Alessio DE SIMONE

Alessio DE SIMONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the modulation of cyclophilins function
    Patent number: 11802108
    Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: October 31, 2023
    Assignee: The University Court of the University of Edinburgh
    Inventors: Julien Michel, Alessio De Simone, Charalampos Ioannidis, Jordi Juarez-Jimenez, Charis Georgiou, Arun Gupta, Alison Hulme, Malcolm Walkinshaw, Dahlia Doughty Shenton
  • CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES
    Publication number: 20230219907
    Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.
    Type: Application
    Filed: December 23, 2020
    Publication date: July 13, 2023
    Applicant: Sitryx Therapeutics Limited
    Inventors: Michael Liam COOKE, David COUSIN, Matthew Colin Thor FYFE, Thomas Michael WAUGH, Saleh AHMED, Alessio DE SIMONE, Barry John TEOBALD
  • COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION
    Publication number: 20210238130
    Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders.
    Type: Application
    Filed: August 29, 2019
    Publication date: August 5, 2021
    Inventors: Julien MICHEL, Alessio DE SIMONE, Charalampos IOANNIDIS, Jordi JUAREZ-JIMENEZ, Charis GEORGIOU, Arun GUPTA, Alison HULME, Malcolm WALKINSHAW, Dahlia DOUGHTY SHENTON
  • Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR)
    Patent number: 9828352
    Abstract: The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar?, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: November 28, 2017
    Assignees: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Giovanni Bottegoni, Alessio De Simone, Gian Filippo Ruda, Andrea Cavalli, Tiziano Bandiera, Daniele Piomelli
  • PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)
    Publication number: 20160194296
    Abstract: The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar?, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
    Type: Application
    Filed: July 10, 2014
    Publication date: July 7, 2016
    Inventors: Giovanni BOTTEGONI, Alessio DE SIMONE, Gian Filippo RUDA, Andrea CAVALLI, Tiziano BANDIERA, Daniele PIOMELLI