Patents by Inventor Alessio Fasano

Alessio Fasano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240368232
    Abstract: The present invention relates to new synthetic molecules with antiviral activity, pharmaceutical compositions comprising them and uses thereof, in particular for the prevention and/or treatment of viral infections such as SARS-COV-2 infections.
    Type: Application
    Filed: April 12, 2022
    Publication date: November 7, 2024
    Inventors: Alessio FASANO, Simone DI MICCO
  • Publication number: 20240218334
    Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
    Type: Application
    Filed: February 5, 2024
    Publication date: July 4, 2024
    Inventors: Alessio Fasano, Timothy K. Lu, Stefania Senger, Maria Eugenia Inda
  • Publication number: 20240197822
    Abstract: The present application relates to extensively hydrolysed protein, and compositions comprising extensively hydrolysed protein, for use in reducing the risk of intestinal inflammation, reducing the risk of intestinal tissue damage, and/or improving gut barrier function, in an infant.
    Type: Application
    Filed: June 24, 2022
    Publication date: June 20, 2024
    Inventors: Alessio FASANO, Gabriele GROSS, Sarmauli Irianti MANURUNG, Stefania SENGER, Eric Alexander Franciscus VAN TOL
  • Publication number: 20240174984
    Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
    Type: Application
    Filed: February 5, 2024
    Publication date: May 30, 2024
    Inventors: Alessio Fasano, Timothy K. Lu, Stefania Senger, Maria Eugenia Inda
  • Patent number: 11926849
    Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: March 12, 2024
    Assignees: The General Hospital Corporation, Massachusetts Institute Of Technology
    Inventors: Alessio Fasano, Timothy K. Lu, Stefania Senger, Maria Eugenia Inda
  • Publication number: 20220218761
    Abstract: Methods for predicting whether a subject will develop a chronic inflammatory condition such as celiac disease, and methods and composition comprising anti-inflammatory microbes or metabolites that can be used to treat or reduce the risk of developing such conditions.
    Type: Application
    Filed: May 6, 2020
    Publication date: July 14, 2022
    Inventors: Maureen M. Leonard, Alessio Fasano, Victoria Kenyon, Ali Zomorrodi
  • Publication number: 20200308549
    Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
    Type: Application
    Filed: March 30, 2020
    Publication date: October 1, 2020
    Inventors: Alessio Fasano, Timothy K. Lu, Stefania Senger, Maria Eugenia Inda
  • Patent number: 10723763
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 28, 2020
    Assignees: ALBA THERAPEUTICS CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Publication number: 20160375089
    Abstract: The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease.
    Type: Application
    Filed: January 26, 2016
    Publication date: December 29, 2016
    Inventors: Alessio Fasano, Blake Paterson
  • Publication number: 20160355551
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 8, 2016
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Publication number: 20160349257
    Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 1, 2016
    Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
  • Publication number: 20160106803
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Application
    Filed: December 16, 2015
    Publication date: April 21, 2016
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Publication number: 20160109444
    Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 21, 2016
    Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
  • Patent number: 9279807
    Abstract: The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: March 8, 2016
    Assignees: ALBA THERAPEUTICS CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Alessio Fasano, Blake Paterson
  • Patent number: 9200258
    Abstract: Disclosed are methods of preparing multi-cellular three-dimensional tissue constructs, that include fibroblasts, endothelial cells, lymphocytes and epithelial cells. The present methods may include embedding fibroblasts and endothelial cells in a matrix enriched with gut basement membrane proteins to form a cell containing matrix that is then added to a bioreactor and exposed to epithelial cells and activated lymphocytes as the cell cultures. Also provided are the tissue constructs formed from such methods, a matrix enriched with gut basement membrane proteins and kits that include the same. Further provided are methods of measuring toxicity of a pathogen or commensal organisms, chemosensitivity of tissues to a toxic material and inflammatory conditions, which use the present multi-cellular three-dimensional tissue constructs.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: December 1, 2015
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Rosangela Mezghanni, Alessio Fasano, Marcelo Sztein
  • Publication number: 20140363818
    Abstract: The present invention provides methods for diagnosing an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a heterozygous or homozygous genotype of haptoglobin 2 or by detecting and quantifying pre-haptoglobin 2 mRNA or protein. After diagnosis, the disease may be treated by decreasing cell permeability leading to increased transepithelial electrical resistance, for example, by administering an antibody directed against single chain zonulin thereby inhibiting epidermal growth factor receptor and inhibiting proteinase-activated receptor 2 (PAR2). Also provided is a single step method for determining severity of an immune-mediated disease in a subject by identifying a genotype for haptoglobin 2 in a biological sample from the subject. A homozygous genotype correlates to 2 copies of zonulin and a more severe disease than a heterozygous genotype correlating to 1 copy of zonulin.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 11, 2014
    Applicant: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Alessio Fasano, Karen Manon Lammers, Terez P. Shea-Donohue, Simeon Glodblum, Craig Sturgeon
  • Publication number: 20140128321
    Abstract: A method for preventing or delaying the onset of autoimmune diseases is disclosed.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 8, 2014
    Applicant: University of Maryland, Baltimore
    Inventors: Alessio Fasano, Tammara L. Watts
  • Publication number: 20140128328
    Abstract: Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 8, 2014
    Applicant: University of Maryland, Baltimore
    Inventor: Alessio Fasano
  • Publication number: 20130295594
    Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
    Type: Application
    Filed: May 1, 2012
    Publication date: November 7, 2013
    Applicants: Alba Therapeutics Corporation, University of Maryland, Baltimore
    Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
  • Publication number: 20130288950
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Application
    Filed: March 28, 2013
    Publication date: October 31, 2013
    Applicants: ALBA THERAPEUTICS CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano