Abstract: Provided herein are methods for the controlled, independent modification of the surface of titanium-based materials and compositions generated thereby. The methods allow for the alteration of multiple surface characteristics including generation of precise nanostructures, morphology, crystallography and chemical composition for increased biocompatibility, for example, osseointegration, osseoconduction, cell adhesion, cell proliferation, mechanical properties (e.g. elasticity, modulus, surface texture, porosity), hydrophobicity, hydrophilicity, steric hindrance, anti-inflammatory properties and/or anti-bacterial properties.