Abstract: A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.

Abstract: A system for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through an injectable nano-network consisting of oppositely-charged dextran nanoparticles encapsulating insulin and glucose-specific enzymes forming a gel-like 3D scaffold. As demonstrated by the examples, the system effectively dissociates to release insulin in a hyperglycemic condition, where the catalytic conversion of glucose into gluconic acid and the subsequent degradation of polymeric matrix are facilitated. This formulation design provides a delivery strategy for both self-regulated and long-term diabetes management.

Abstract: An apparatus to enhance oil extraction from pores of a bowling ball includes a housing unit with an opening, a tank disposed within the opening and able to store a fluid, a rack disposed within the tank to secure the bowling ball in a stationary position and orient the ball such that at least one finger hole of the ball is positioned above an upper level of the stored fluid, a heating unit coupled to the tank to heat the stored fluid, and at least one ultrasonic transducer coupled to the tank. The at least one transducer directs sound waves through the heated fluid toward the secured bowling ball, thereby extracting oil from the bowling ball.

Abstract: A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.

Abstract: An apparatus to enhance oil extraction from pores of a bowling ball includes a housing unit with an opening, a tank disposed within the opening and able to store a fluid, a rack disposed within the tank to secure the bowling ball in a stationary position and orient the ball such that at least one finger hole of the ball is positioned above an upper level of the stored fluid, a heating unit coupled to the tank to heat the stored fluid, and at least one ultrasonic transducer coupled to the tank. The at least one transducer directs sound waves through the heated fluid toward the secured bowling ball, thereby extracting oil from the bowling ball.

Abstract: A digital paper-enabled product includes digital paper with a digital pattern that spatially cooperates with one or more features or boundaries printed on the pattern. More specifically, a system cooperating with the product may include spatial information systems that manage the features or boundaries and communicates with a writing instrument that was used to effect changes to the digital paper-enabled product. In one embodiment, the digital paper-enabled product may take the form of a sheet of digital paper bearing a digital pattern and where action icons (e.g. user intended actions) and/or features (e.g. such as map features) or a spatial reference frame are printed onto the digital pattern and where at least one action palette is printed onto the digital pattern, correlated therewith, and usable to effect changes to the product.

Abstract: A digital paper-enabled product includes digital paper with a digital pattern that spatially cooperates with one or more features or boundaries printed on the pattern. More specifically, a system cooperating with the product may include spatial information systems that manage the features or boundaries and communicates with a writing instrument that was used to effect changes to the digital paper-enabled product. In one embodiment, the digital paper-enabled product may take the form of a sheet of digital paper bearing a digital pattern and where action icons (e.g. user intended actions) and/or features (e.g. such as map features) or a spatial reference frame are printed onto the digital pattern and where at least one action palette is printed onto the digital pattern, correlated therewith, and usable to effect changes to the product.

Abstract: Methods and systems for multimedia object association to digital paper spatial diagrams are disclosed herein. A method for multimedia object association to digital paper spatial diagrams includes the steps of (1) capturing a media object to be imported into a spatial information system; (2) linking the captured media object to a digital paper document containing a spatial diagram, using a input device configured to select a linking action area located in a first area of the digital paper document and configured to select a location for the captured multimedia data object on a second area of the digital paper document; (3) transferring the media object and the data from the input device to a spatial information system; and (4) combining the media object and the data of the input device to create an updated digital paper document containing the media object.