Patents by Inventor Alex Alder

Alex Alder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6165800
    Abstract: A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: December 26, 2000
    Assignee: Bayer Corporation
    Inventors: Qingping Jiang, Jun Xi, Anand Natrajan, David Sharpe, Marcus Baumann, Rolf Hilfiker, Erika Schmidt, Paul Senn, Fritz Thommen, Adrian Waldner, Alex Alder, Say-Jong Law
  • Patent number: 6143570
    Abstract: A composition comprising(a) a transparent support(b) which is coated on at least one side with a transparent coating which comprises(b1) a plasticizer-free, hydrophobic polymer having a glass transition temperature Tg of from -150 to 50.degree. C.,(b2) counterions in the form of lipophilic salts,(b3) an ionophore which forms a complex with the ion to be determined, and(b4) a compound of the formula I or II as fluorophore ##STR1## in which R.sub.1 and R.sub.3, and R.sub.4 and R.sub.6 are C.sub.1 -C.sub.30 alkyl or C.sub.1 -C.sub.30 alkyl-CO--, and R.sub.2 and R.sub.5 are H or C.sub.1 -C.sub.30 alkyl, with the proviso that the total number of carbon atoms in the alkyl groups is at least 5, or a salt thereof with an inorganic or organic acid. The composition is highly suitable for the qualitative or quantitative optical determination of ions by fluorescence detection.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: November 7, 2000
    Assignee: Novartis Corporation
    Inventors: Alex Alder, Steven Barnard, Joseph Berger
  • Patent number: 5922612
    Abstract: A method for the independent, reversible, optical determination of the pH value and the ionic strength of an aqueous sample with the aid of two different sensors in accordance with the fluorescence method, in which method two optical sensors, which are each composed of polymers of different structure but each contain the same fluorescent dye and which each consist of a coated material composed ofa) a carrier material, to which there is appliedb) at least one water-insoluble layer of a polymer comprising at least one hydrophilic monomer (A) from the group of substituted olefins, andc) a proton-sensitive fluorescent dye which is bonded directly or via a bridge group to the spine of polymer b) or which is incorporated in polymer b),are brought into contact with an aqueous test sample, irradiated with exciting light, the fluorescence is measured and the pH values and the ionic strengths are calculated from the measured fluorescence intensities with reference to calibration curves.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: July 13, 1999
    Assignee: Novartis Corporation
    Inventors: Alex Alder, Steven Barnard, Joseph Berger, Nils Blom, Marizel Rouilly
  • Patent number: 5206388
    Abstract: The reaction of 5,6,11,12-tetrachlorotetracene with thiourea and sulfur in a polar aprotic solvent yields 5,6,11,12-tetrathiotetracene in high yield and purity. This compound is an electron donor for forming electrically conductive radical cation salts with electron donors.
    Type: Grant
    Filed: April 22, 1992
    Date of Patent: April 27, 1993
    Assignee: Ciba-Geigy Corporation
    Inventor: Alex Alder
  • Patent number: 5106872
    Abstract: The insecticidal and acaricidal activity of N-phenylthioureas can be enhanced and prolonged by the simultaneous application of photosensitizers, and this activity can also be effected within a shorter period of time after application.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: April 21, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Alex Alder, Alfred Rindlisbacher, Hans-Peter Streibert, Rudolf Banninger
  • Patent number: 4990232
    Abstract: The photooxidation of N,N'-substituted thioureas with oxygen in the presence of an acid-trapping agent gives N,N'-substituted carbodiimides. The carbodiimides can be converted into cyanoguanidines, which are suitable as latent curing agents for epoxy resins.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: February 5, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Alex Alder
  • Patent number: 4883877
    Abstract: Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, for example, H, alkyl, cycloalkyl, aryl or alkaryl are suitable as an ammonium salt-forming component for acid pharmaceutical active ingredients, and in particular for the preparation of azabicyclo[3.1.1.]heptane-substituted alkanediphosphonic acids for the treatment of diseases which can be attributed to disturbances in calcium metabolism.
    Type: Grant
    Filed: October 31, 1988
    Date of Patent: November 28, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Alex Alder
  • Patent number: 4859761
    Abstract: Curable epoxy resin compositions containing cyanoguanidines of formula I ##STR1## wherein, for example, R.sup.1 and R.sup.2 are phenyl, as latent hardeners, have good properties and are especially suitable for use as laminating resins.
    Type: Grant
    Filed: August 30, 1988
    Date of Patent: August 22, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Flury, Alex Alder
  • Patent number: 4857660
    Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
    Type: Grant
    Filed: April 22, 1988
    Date of Patent: August 15, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Alex Alder, Jaroslav Stanek, Daniel Bellus
  • Patent number: 4764640
    Abstract: 1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: August 16, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Alex Alder, Jaroslaw Stanek, Daniel Bellus
  • Patent number: 4677129
    Abstract: 1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
    Type: Grant
    Filed: June 20, 1985
    Date of Patent: June 30, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Alex Alder, Jaroslav Stanek, Daniel Bellus